Title

Tissue destruction in periodontitis: Bacteria or cytokines fault?

Authors

Bascones, Antonio; Noronha, Susana; Gómez, Maria; Mota, P.; Moles, M. A. Gónzalez; Dorrego, Mariana Villarroel

Abstract

The pathogenesis of periodontal disease involves the sequential activation of a great variety of components of the host immune response, primarily acting to defend periodontal tissues against bacterial aggression, but also functioning as mediators of tissue destruction. The expression of the disease results from the interaction of host, microbiological agents, and environmental factors. Leukocytes play a critical role in the pathogenesis of the disease, producing different cytokines, chemokines, and other mediators, thus generating a host defense response, as well as inducing tissue inflammation and bone destruction. The aim of this review is to address the role of some inflammatory mediators in response to bacterial aggression in periodontitis. (Quintessence/nt 2005,36.299-306)

Subjects

PERIODONTITIS; CHEMOKINES; CYTOKINES; IMMUNOLOGY; INTERLEUKINS; LYMPHOCYTES

Publication

Quintessence International, 2005, Vol 36, Issue 4, p299

ISSN

0033-6572

Publication type

Academic Journal