Title

Synthesis of Lactosidated Derivatives of Genistein.

Authors

Song Guo-hui; Deng Ze-yuan; Cao Shu-wen; Yu Yan-ying; Liu Rong

Abstract

To improve the targeting activity of genistein in vivo, chemical modification for genistein was carried out by using lactose, which has the potential selective affinity to the surface receptors of cancer cells. Two new compounds, genistein 7-O-β-D-lactoside (4) and genistein 7,4'-di-O-β-D-lactoside (5), were synthesized from unprotected genistein by means of phase transfer catalysis. They were characterized by IR, ¹H NMR, 13C NMR and MS spectral data.

Subjects

ORGANIC synthesis; LACTOSE; CANCER cells; CATALYSIS; INFRARED spectroscopy

Publication

Natural Product Research & Development, 2007, Vol 19, Issue 6, p948

ISSN

1001-6880

Publication type

Academic Journal