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Title: Antiviral Effect of Glycyrrhizin on Porcine Respiratory Coronavirus (PRCV).
Authors: Cao Min-Jie; Wu Guo-Ping; Weng Ling; Su Wen-Jin
Abstract: The inhibitory effect of glycyrrhizin (GL) on porcine respiratory coronavirus (PRCV) replication was investigated in vitro in ST cells using RT-PCR and Western blot techniques. GL effectively suppressed PRCV replication without causing apparent cell cytotoxicity in ST cells. The inhibitory effect of GL on PRCV was in a dose-dependent manner. The expression levels of both mRNA and protein of the PRCV nucleocapsid protein in ST cells were impeded by the increasing addition of GL, suggesting it is a potential effective antiviral component against PRCV in vitro.
Subjects: ANTIVIRAL agents; GLYCYRRHIZA; CORONAVIRUSES; VIRAL replication; MESSENGER RNA; PROTEINS
Publication: Natural Product Research & Development, 2007, Vol 19, Issue 2, p221
ISSN: 1001-6880
Publication type: Academic Journal

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Antiviral Effect of Glycyrrhizin on Porcine Respiratory Coronavirus (PRCV).