Title

Antiviral Effect of Glycyrrhizin on Porcine Respiratory Coronavirus (PRCV).

Authors

Cao Min-Jie; Wu Guo-Ping; Weng Ling; Su Wen-Jin

Abstract

The inhibitory effect of glycyrrhizin (GL) on porcine respiratory coronavirus (PRCV) replication was investigated in vitro in ST cells using RT-PCR and Western blot techniques. GL effectively suppressed PRCV replication without causing apparent cell cytotoxicity in ST cells. The inhibitory effect of GL on PRCV was in a dose-dependent manner. The expression levels of both mRNA and protein of the PRCV nucleocapsid protein in ST cells were impeded by the increasing addition of GL, suggesting it is a potential effective antiviral component against PRCV in vitro.

Subjects

ANTIVIRAL agents; GLYCYRRHIZA; CORONAVIRUSES; VIRAL replication; MESSENGER RNA; PROTEINS

Publication

Natural Product Research & Development, 2007, Vol 19, Issue 2, p221

ISSN

1001-6880

Publication type

Academic Journal