Title

Role of Flavonoids and Vitamins in Cancer.

Authors

Luisa Castellani, Maria; Shaik, Yazdani B.; Narayan Shanmugham, Lakshmi; Frydas, Stavros; Madhappan, Bhuvaneshwari; Salini, Vincenzo; Vecchiet, Jacopo; Mastrangelo, Filiberto; Riccioni, Graziano; Conti, Fiorella; Perrella, Alessandro; Conti, Pio; Tetè, Stefano

Abstract

Flavonoids are naturally occurring polyphenolic plant compounds that are capable of inhibiting histamine and cytokine release from several cells. Many studies suggest that flavonoids are anticancer agents with an apoptotic effect on tumor cells. Studies with animal tumour models have found vitamin deficiency to enhance susceptibility to chemical carcinogenesis and large doses of anti-oxidant vitamins and flavonoids to inhibit carcinogenesis. In some studies flavonoids and/or vitamins were found to reduce the predisposition to develop tumours in animals and humans. In conclusion, in this review we describe the role of flavonoids and vitamins in cancer.

Subjects

FLAVONOIDS; ANTINEOPLASTIC agents; CANCER cells; VITAMIN therapy; VITAMIN deficiency; ANIMAL models of chemical carcinogenesis; THERAPEUTICS

Publication

Biology Forum / Rivista di Biologia, 2007, Vol 100, Issue 1, p39

ISSN

1825-6538

Publication type

Academic Journal