The Relationship Between Serum Sex Hormone-Binding Globulin and Vascular Endothelial Dysfunction in Type 2 Diabetes.

Se Eun Park; Ji Young Lee; Jae Hyuk Lee; Eun Seok Kang; Chul Woo Ahn; Hyun Chul Lee; Bong Soo Cha

Sex hormone-binding globulin (SHBG) are down-regulated by insulin and could serve as potential indicators of the metabolic syndrome and hyperinsulinemia-related cardiovascular risk. The purpose of this study was to investigate the relationship between serum SHBG and vascular endothelial dysfunction in type 2 diabetic patients. The study subjects included 31 newly diagnosed type 2 diabetic patients (age 29-70, mean age 50±10.0, 61.3% male). There was no patient taking any drugs that could affect glucose metabolism and endothelial function. Serum SHBG concentration was measured by radioimmunoassay. The Flow-mediated dilatation (FMD) of brachial artery was performed to examine endothelial dysfunction. The median and mean values of SHBG were 46 and 54±27.8 nmol/L, respectively (range 12-106 nmol/L). Log[sub 10] (SHBG) was positively correlated with age (r =0.498, P <0.05) and FMD (r = 0.417, P <0.05), but negatively correlated with HOMA[sub IR] (r= - 0.516, P <0.05) and monocyte count (r = -0.369, P <0.05). In multiple regression analysis after an adjustment for age, monocyte count and HOMA[sub IR], log[sub 10](SHBG) showed significant correlation with FMD (β = 0.485, P = 0.007). This study shows that serum SHBG levels are significantly associated with endothelial function. SHBG might be a surrogate marker of both insulin resistance and endothelial dysfunction in type 2 diabetes.

SEX hormones; GLOBULINS; PEOPLE with diabetes; METABOLIC syndrome; INSULIN resistance; GLUCOSE; METABOLISM; RADIOIMMUNOASSAY

Diabetes, 2007, Vol 56, pA593

0012-1797

Academic Journal