Works matching DE "DRUG development"

Results: 5000

Overproduction of endusamycin in Streptomyces endus subsp. aureus.

Published in:

Synthetic & Systems Biotechnology, 2025, v. 10, n. 2, p. 523, doi. 10.1016/j.synbio.2025.02.004

By:

Yingying Chang;
Zhen Liu;
Zixin Deng;
Tiangang Liu

Publication type:

Article

FairChain : A Trusted and Transparent Blockchain-Based Ecosystem for Drug Development for Nagoya Protocol Implementation.

Published in:

Electronics (2079-9292), 2025, v. 14, n. 13, p. 2527, doi. 10.3390/electronics14132527

By:

AlSalamah, Shada;
Alnehmi, Shaima A.;
Abanumai, Anfal A.;
Alnashri, Asmaa H.;
Alduhim, Sara S.;
Alnamlah, Norah A.;
AlGhamdi, Khulood;
Sheerah, Haytham A.;
Alsalamah, Sara A.;
Alsalamah, Hessah A.

Publication type:

Article

Establishment of an Orthotopic and Metastatic Colorectal Cancer Mouse Model Using a Tissue Adhesive-Based Implantation Method.

Published in:

Cancers, 2025, v. 17, n. 13, p. 2266, doi. 10.3390/cancers17132266

By:

Lee, Sang Bong;
Jeon, Hui-Jeon;
Hyun, Hoon;
Jeon, Yong Hyun

Publication type:

Article

Advances in Supportive Care for Multiple Myeloma-Related Bone Disease—A Review.

Published in:

Cancers, 2025, v. 17, n. 13, p. 2166, doi. 10.3390/cancers17132166

By:

Abbas, Saadia;
Adil, Haleema Sadia;
Raza, Shahzad;
Basit, Janita;
Arul, Karan;
Anwer, Faiz;
Habib, Muhammad Hamza

Publication type:

Article

Optimizing Preclinical Models for Oral Cancer: The Influence of 4NQO Administration Routes on Tumor Development.

Published in:

Cancers, 2025, v. 17, n. 13, p. 2108, doi. 10.3390/cancers17132108

By:

Van den Bosch, Jolien;
Caz, Nuran;
Martens, Sandrina;
Erens, Céline;
Rasking, Leen;
Gervois, Pascal;
Nijsten, Kim;
Himmelreich, Uwe;
Van Cauter, Sofie;
Hillen, Lisa M.;
Plasschaert, Herbert;
Lambrichts, Ivo;
Wolfs, Esther

Publication type:

Article

Identification and Characterization of Novel Inhibitors of Human Poly(ADP-Ribose) Polymerase-1.

Published in:

Molecules, 2025, v. 30, n. 13, p. 2728, doi. 10.3390/molecules30132728

By:

Morgan, Ibrahim;
Rennert, Robert;
Berger, Robert;
Hassanin, Ahmed;
Davari, Mehdi D.;
Eisenschmidt-Bönn, Daniela;
Wessjohann, Ludger A.

Publication type:

Article

Purification and Inhibitor Screening of the Full-Length SARS-CoV-2 Nucleocapsid Protein.

Published in:

Molecules, 2025, v. 30, n. 13, p. 2679, doi. 10.3390/molecules30132679

By:

Chen, Chen;
Zhang, Zhengfu;
Zheng, Qiao;
Zhou, Yingshun;
Zhang, Shujun

Publication type:

Article

Mutant p53 as a Therapeutic Target: The Report of Its Death Was an Exaggeration.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6446, doi. 10.3390/ijms26136446

By:

Toledo, Franck

Publication type:

Article

Parkinson Disease Signaling Pathways, Molecular Mechanisms, and Potential Therapeutic Strategies: A Comprehensive Review.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6416, doi. 10.3390/ijms26136416

By:

Khan, Muhammad S.;
Nasiripour, Somayyeh;
Bopassa, Jean C.

Publication type:

Article

Triazole-imidazo[1,2- b ]pyrazoles Able to Counteract Melanoma Cell Survival Without Compromising the Viability of Healthy Keratinocytes.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6312, doi. 10.3390/ijms26136312

By:

Brullo, Chiara;
Marengo, Barbara;
Domenicotti, Cinzia;
Lusardi, Matteo;
Cichero, Elena;
Salis, Annalisa;
Caviglia, Debora;
Russo, Eleonora;
Spallarossa, Andrea

Publication type:

Article

Drug Repurposing for Rare (Orphan) Diseases—Scope and Limitations.

Published in:

Apollo Medicine, 2025, v. 22, n. 4, p. 329, doi. 10.1177/09760016241287308

By:

Kumar, Dhavendra

Publication type:

Article

Melatonin for hair regrowth: Preclinical insights, current evidence, and future perspectives.

Published in:

Electronic Journal of General Medicine, 2025, v. 22, n. 4, p. 1, doi. 10.29333/ejgm/16520

By:

Tawanwongsri, Weeratian;
Eden, Chime

Publication type:

Article

Research progress on active components in fruits of Panax plants and its processing and utilization.

Published in:

Food & Machinery, 2025, n. 6, p. 244, doi. 10.13652/j.spjx.1003.5788.2025.80355

By:

KONG Linghui;
CHEN Haining;
WANG Yingxiu;
JIANG Mengmeng;
LI Xiangguo;
HAN Lianhua

Publication type:

Article

Unveiling the Diversity of Culturable Microbes from the Underexplored Mingyong Glacier Landscape: A Roadmap for Leveraging the Potential of Actinomycetota.

Published in:

Indian Journal of Microbiology, 2025, v. 65, n. 2, p. 749, doi. 10.1007/s12088-025-01449-0

By:

Saravana Kumar, Pachaiyappan;
Xiang, Changjun;
Zhang, Lihan

Publication type:

Article

Recent advances and applications of mitochondria in tumors and inflammation.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06722-w

By:

Liu, Hui;
Pan, Mengmeng;
Li, Yumeng;
Huang, Zhen;
Li, Hanying;
Zhang, Chenguang;
Guo, Chunlei;
Wang, Hui

Publication type:

Article

Challenges to Establishing Pharmaceutical Medicine as a Profession: Needs for Professional Identity and a Career Pathway: Role of Education and Training.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 4, p. 235, doi. 10.1007/s40290-025-00559-w

By:

Silva, Honorio;
Baroutsou, Varvara;
Criscuolo, Domenico;
Guptha, Soneil;
Jurczynska, Anna;
Kerpel-Fronius, Sandor;
Klech, Heinrich;
Klingmann, Ingrid

Publication type:

Article

Embracing Medicines Development as a Profession.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 4, p. 215, doi. 10.1007/s40290-025-00556-z

By:

Chopra, Pravin

Publication type:

Article

Professional Competencies and Capabilities in the Development of Medicines.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 4, p. 225, doi. 10.1007/s40290-025-00550-5

By:

Stonier, Peter D.;
Jones, Stuart A.

Publication type:

Article

The Value and Importance of a Professional Ethical Code for Medicines Development: IFAPP International Ethics Framework.

Published in:

Pharmaceutical Medicine, 2025, v. 39, n. 4, p. 249, doi. 10.1007/s40290-024-00547-6

By:

Kerpel-Fronius, Sandor;
Becker, Alexander L.

Publication type:

Article

Antibiotic Resistance: How Podiatrists can help to avert a Global Catastrophe.

Published in:

Podiatry Review, 2025, v. 82, n. 3, p. 25

By:

Newport, Graham

Publication type:

Article

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.

Published in:

Science Translational Medicine, 2025, v. 17, n. 806, p. 1, doi. 10.1126/scitranslmed.adu4564

By:

Tulloch, Lindsay B.;
Tawell, Hugh;
Taylor, Annie E.;
Lima, Marta Lopes;
Dawson, Alice;
Carvalho, Sandra;
Wall, Richard J.;
Corpas-Lopez, Victoriano;
Dey, Gourav;
Duggan, Jack;
Magalhaes, Luma Godoy;
Torrie, Leah S.;
Frame, Laura;
Robinson, David;
Patterson, Stephen;
Tinti, Michele;
Weaver, George W.;
Robinson, William J.;
Cal, Monica;
Kaiser, Marcel

Publication type:

Article

The Evolution of Pharmaceutical Solids: From Early Polymorphism to Cutting-Edge Drug Development.

Published in:

Croatica Chemica Acta, 2025, v. 97, n. 4, p. 243, doi. 10.5562/cca4154

By:

Danilovski, Aleksandar;
Meštrović, Ernest

Publication type:

Article

Optimizing public-private partnerships to support clinical cancer research.

Published in:

JNCI: Journal of the National Cancer Institute, 2025, v. 117, n. 7, p. 1305, doi. 10.1093/jnci/djae279

By:

Herbst, Roy S;
Blumenthal, Gideon;
Khleif, Samir N;
Lippman, Scott M;
Meropol, Neal J;
Rosati, Kristen;
Shulman, Lawrence N;
Smith, Heind;
Wang, Meina;
Winn, Robert A;
Schilsky, Richard L

Publication type:

Article

Comparison of in silico predictions of action potential duration in response to inhibition of IKr and ICaL with new human ex vivo recordings.

Published in:

PLoS Computational Biology, 2025, v. 21, n. 7, p. 1, doi. 10.1371/journal.pcbi.1012913

By:

Barral, Yann-Stanislas H. M.;
Polonchuk, Liudmila;
Clerx, Michael;
Gavaghan, David J.;
Mirams, Gary R.;
Wang, Ken

Publication type:

Article

Applied intelligence in clinical drug development: Potential benefits and emerging concerns.

Published in:

Perspectives in Clinical Research, 2025, v. 16, n. 3, p. 127, doi. 10.4103/picr.picr_37_25

By:

Bhatt, Arun

Publication type:

Article

MRDDA: a multi-relational graph neural network for drug–disease association prediction.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06783-x

By:

Chen, Congzhou;
Zhou, Yaozheng;
Li, Yinghong;
Xu, Jin;
Li, Demin;
Wang, Lingfeng

Publication type:

Article

Understanding the gap between expectations and reality in decentralized clinical trials.

Published in:

NPJ Digital Medicine, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s41746-025-01811-y

By:

Jiang, Yale;
Leng, Ye;
Wu, Qing;
Hou, Yiru;
Dong, Xueyuan;
Zeng, Caiwen;
Wu, Dawei;
Fang, Hong;
Tang, Yu;
Huang, Huiyao;
Li, Ning

Publication type:

Article

Charting the academic output on cyanobacterial exopolysaccharides and their industrial applications.

Published in:

Studia Universitatis Babeş-Bolyai, Biologia, 2025, v. 70, n. 1, p. 1

By:

BOCANEALA, Maricel;
GORON, Giovani M.;
RAKOSY-TICAN, Elena

Publication type:

Article

Preclinical Evaluation of a Poly (Lactic Acid/Caprolactone) Bilayer Membrane and a Carbonate Apatite for Periodontal Regeneration: A Canine One‐Wall Intrabony Defect Model.

Published in:

Journal of Periodontal Research, 2025, v. 60, n. 5, p. 504, doi. 10.1111/jre.13355

By:

Yamaki, Daichi;
Fukuba, Shunsuke;
Okada, Munehiro;
Takeuchi, Shunsuke;
Hoshi, Shu;
Schmidlin, Patrick R.;
Iwata, Takanori

Publication type:

Article

A Comprehensive Review on Chromene Derivatives: Potent Anti-Cancer Drug Development and Therapeutic Potential.

Published in:

Oriental Journal of Chemistry, 2025, v. 41, n. 2, p. 584, doi. 10.13005/ojc/410229

By:

MOHAMED, HANY M.

Publication type:

Article

MULTIOMICS INTEGRATION IN ANTI-TUBERCULOSIS DRUG DISCOVERY.

Published in:

Sanamed, 2025, v. 20, n. 1, p. 89, doi. 10.5937/sanamed0-51644

By:

Abubakar, Yaro

Publication type:

Article

An update on Linezolid resistance in Mycobacterium tuberculosis and the challenges ahead.

Published in:

Egyptian Journal of Chest Diseases & Tuberculosis, 2025, v. 74, n. 3, p. 267, doi. 10.4103/ecdt.ecdt_81_24

By:

Singh, Anupriya;
Chauhan, Varsha;
Kumar, Chanchal;
Varma-Basil, Mandira;
Prakash, Anupam

Publication type:

Article

A deep learning-based method for predicting the frequency classes of drug side effects based on multi-source similarity fusion Open Access.

Published in:

Bioinformatics, 2025, v. 41, n. 6, p. 1, doi. 10.1093/bioinformatics/btaf319

By:

Zhao, Haochen;
Li, Dingxi;
Zhong, Jian;
Liang, Xiao;
Duan, Guihua;
Wang, Jianxin

Publication type:

Article

Pharmaceutical Innovation Through Computational Drug Design: A Comprehensive Exploration.

Published in:

Makara Journal of Science, 2025, v. 29, n. 2, p. 216, doi. 10.7454/mss.v29i2.2629

By:

Chandramouli, Manasa;
Surendra, Madhusudhan Heggadadevanakote

Publication type:

Article

IAT + AHSCT - postavení vysokodávkované imunoablativní léčby s autologní transplantací hematopoetických kmenových buněk u pacientů s roztroušenou sklerózou.

Published in:

Neurologie Pro Praxi, 2025, v. 26, n. 3, p. 197, doi. 10.36290/neu.2025.010

By:

Hradílek, Pavel

Publication type:

Article

Quantitative Solid‐State NMR Spectroscopy (qSSNMR) in Pharmaceutical Analysis.

Published in:

Magnetic Resonance in Chemistry, 2025, v. 63, n. 8, p. 585, doi. 10.1002/mrc.5536

By:

Zheng, Zhaoxi;
Chen, Kang;
Liu, Yang;
Munson, Eric J.;
Su, Yongchao

Publication type:

Article

Treatment-related adverse events of antibody drug-conjugates in clinical trials.

Published in:

Journal of Hematology & Oncology, 2025, v. 18, n. 1, p. 1, doi. 10.1186/s13045-025-01720-3

By:

Tan, Harold Nathan;
Morcillo, Marta Ascanio;
Lopez, Juanita;
Minchom, Anna;
Sharp, Adam;
Paschalis, Alec;
Silva-Fortes, Georgina;
Raobaikady, Bindu;
Banerji, Udai

Publication type:

Article

Exploring the supraspinal antihyperalgesic effects of levetiracetam in the rat model of chronic constriction injury.

Published in:

Canadian Journal of Physiology & Pharmacology, 2025, v. 103, n. 7, p. 244, doi. 10.1139/cjpp-2024-0302

By:

Altinok, Feyza Alyu;
Petrella, Michele;
Masi, Alessio;
Borruto, Anna Maria;
Ciccocioppo, Roberto;
Ozturk, Yusuf

Publication type:

Article

SIMULATING NUCLEAR REACTIONS FOR OPTIMIZED PRODUCTION OF THERANOSTIC RADIONUCLIDES 124I AND 131I.

Published in:

Bayero Journal of Pure & Applied Sciences, 2024, v. 15, p. 264, doi. 10.4314/bajopas.v15i1.41S

By:

Zubaida, G. H.;
Koki, F. S.;
Ahmad, I.

Publication type:

Article

From Patents to Regulatory Exclusivities in Drug Development: A Comparative Transaction CostAnalysis.

Published in:

Jurimetrics: The Journal of Law, Science & Technology, 2024, v. 64, n. 4, p. 75

By:

Morgan, Maxwell;
Gold, E. Richard

Publication type:

Article

Anticancer effect of ethanolic yellow hawthorn extract on chronic myeloid leukemia cells and acute myeloid leukemia cells.

Published in:

Journal of Experimental & Clinical Medicine / Deneysel ve Klinik Tip Dergisi, 2025, v. 42, n. 2, p. 119, doi. 10.52142/omujecm.42.2.4

By:

ARSLAN, Ayşe Nur;
AKÇOK, İsmail

Publication type:

Article

Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.

Published in:

BMC Infectious Diseases, 2025, v. 25, n. 1, p. 1, doi. 10.1186/s12879-025-11227-4

By:

Yang, Chen;
Dai, Guangchuan;
Guo, Yicheng;
Wang, Tianzhen;
Gao, Weiwei;
Zeng, Yi

Publication type:

Article

AMCL: supervised contrastive learning with hard sample mining for multi-functional therapeutic peptide prediction.

Published in:

BMC Biology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12915-025-02273-0

By:

Fang, Jiwei;
Fan, Henghui;
Zhao, Jintao;
Zhao, Jianping;
Xia, Junfeng

Publication type:

Article

Joint fusion of sequences and structures of drugs and targets for identifying targets based on intra and inter cross-attention mechanisms.

Published in:

BMC Biology, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12915-025-02256-1

By:

Zeng, Xin;
Su, Guang-Peng;
Du, Wen-Feng;
Jiang, Bei;
Li, Yi;
Yang, Zi-Zhong

Publication type:

Article

Single atom engineering for radiotherapy-activated immune agonist prodrugs.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-60768-4

By:

Ding, Zexuan;
Yin, Xiaozhe;
Zheng, Yuedan;
Li, Yiyan;
Ge, Huanhuan;
Feng, Jianshu;
Wang, Ziyang;
Qiao, Simiao;
Sun, Qi;
Yu, Fashuo;
Hou, Zhanshan;
Fu, Yang-Xin;
Liu, Zhibo

Publication type:

Article

Phytochemical composition and bioactivity of Debregeasia saeneb leaves: Insights into anti-diabetic and antioxidant properties.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0326991

By:

Khan, Rashid;
Afza, Rabia;
Ahmad, Bashir;
Miskeen, Sumaira;
Ahmad, Khalid;
Abdel-Maksoud, Mostafa A.;
Alrokayan, Salman;
Y. Zaky, Mohamed

Publication type:

Article

Financing drug development via adaptive platform trials.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0325826

By:

Cho, Joonhyuk;
Sorets, Eugene;
Chaudhuri, Shomesh;
De Mattos, Annette;
Drake, Kristin;
Cudkowicz, Merit E.;
Ortiz, Ricardo;
Hasenoehrl, Meredith;
Chase, Marianne;
Harkey, Brittney;
Paganoni, Sabrina;
Frishkopf, John;
Lo, Andrew W.

Publication type:

Article

Overstating harms can have consequences.

Published in:

Brain: A Journal of Neurology, 2025, v. 148, n. 6, p. e52, doi. 10.1093/brain/awaf046

By:

Bedlack, Richard S

Publication type:

Article

Roadmap to Cytotoxicity: Exploring Assays and Mechanisms.

Published in:

Assay & Drug Development Technologies, 2025, v. 23, n. 5, p. 217, doi. 10.1089/adt.2024.109

By:

Shekhawat, Kirtivardhan Singh;
Bhatia, Piyush;
Bhatnagar, Kartik;
Shandilay, Swati;
Chaudhary, Sarika

Publication type:

Article

FAP inhibitors: are we really using the best method to evaluate the residence time?

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2025, v. 52, n. 9, p. 3062, doi. 10.1007/s00259-025-07160-y

By:

Cortesi, Michela;
Guerrini, Remo;
Roccatello, Chiara;
Pacifico, Salvatore;
Albanese, Valentina;
Ulivi, Paola;
Paganelli, Giovanni;
Bravaccini, Sara

Publication type:

Article