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- Title
THE PHARMACOLOGY OF AFROSIDE B -- A NEW CARDIAC GLYCOSIDE.
- Authors
Rand, M. J.; Stafford, Anne
- Abstract
A pharmacological investigation has been carried out on afroside B, a new crystalline cardiac glycoside from Gomphocarpus fruticosus. It has been shown to have a typical positive inotropic action on the cat papillary muscle and the guinea-pig Langendorff heart. The toxicity of afroside B has been determined by intravenous infusion in the cat and the guinea-pig and also on the isolated embryonic chick heart. Afroside B is rapidly inactivated by passage through the guinea-pig liver in situ. The heart block produced in the guinea-pig by regular intra-atrial injections of adenosine is potentiated by non-toxic doses of afroside B.
- Subjects
CARDIAC glycosides; GOMPHOCARPUS fruticosus; CATS; GUINEA pigs; MUSCLES
- Publication
Australian Journal of Experimental Biology & Medical Science, 1955, Vol 33, Issue 5, p527
- ISSN
0004-945X
- Publication type
Academic Journal
- DOI
10.1038/icb.1955.54