Title

THE PHARMACOLOGY OF AFROSIDE B -- A NEW CARDIAC GLYCOSIDE.

Authors

Rand, M. J.; Stafford, Anne

Abstract

A pharmacological investigation has been carried out on afroside B, a new crystalline cardiac glycoside from Gomphocarpus fruticosus. It has been shown to have a typical positive inotropic action on the cat papillary muscle and the guinea-pig Langendorff heart. The toxicity of afroside B has been determined by intravenous infusion in the cat and the guinea-pig and also on the isolated embryonic chick heart. Afroside B is rapidly inactivated by passage through the guinea-pig liver in situ. The heart block produced in the guinea-pig by regular intra-atrial injections of adenosine is potentiated by non-toxic doses of afroside B.

Subjects

CARDIAC glycosides; GOMPHOCARPUS fruticosus; CATS; GUINEA pigs; MUSCLES

Publication

Australian Journal of Experimental Biology & Medical Science, 1955, Vol 33, Issue 5, p527

ISSN

0004-945X

Publication type

Academic Journal

DOI

10.1038/icb.1955.54