Title

THE EFFECT OF CARDIAC GLYCOSIDES ON THE HEART BLOCK PRODUCED IN THE GUINEA-PIG BY ADENOSINE AND ITS DERIVATIVES.

Authors

Rand, M.; Stafford, Anne; Thorp, R. H.

Abstract

Adenosine, adenylic acid and A.T.P. injected into the left atrium in equimolecular doses produce a quantitatively and qualitatively identical period of heart block in the guinea-pig. Small doses of ouabain, insufficient to have any other effect on the E.C.G., potentiate the effect of these three adenyl compounds to the same extent. Coenzyme I has a qualitatively similar action to adenosine on the guinea-pig E.C.G., but this effect is potentiated to a greater extent by ouabain than is the response to the other adenyl compounds. Digoxin, digitoxin and lanatoside C in small doses also potentiated the effect of adenosine on the guinea-pig heart; lanatoside C is less active in this respect than the other cardiac glycosides. It has been shown that the rate of development of potentiation of the response to adenosine is proportional to the rate of infusion of the cardiac glycoside.

Subjects

HEART; GLYCOSIDES; GLUCOSIDES; HEART block; GUINEA pigs; ADENOSINES

Publication

Australian Journal of Experimental Biology & Medical Science, 1955, Vol 33, Issue 6, p663

ISSN

0004-945X

Publication type

Academic Journal

DOI

10.1038/icb.1955.67