Title

The anti-inflammatory effects of cetirizine.

Authors

Walsh, G. M.

Abstract

This article discusses the anti-inflammatory effects of cetirizine. Cetirizine seems to have a particular effect on the eosinophil and may be acting via a defined intracellular signaling pathway. It also discusses work on the effect of cetirizine on the biochemistry of inflammatory cell function would have to be performed. The body of data from in vitro, in vivo and ex vivo studies confirms that cetirizine does have a number of interesting anti-inflammatory properties in addition to its H 1 anti-histamine activity. However, more work is still required to fully dissect the mechanism(s) by which this drug is acting. This new knowledge might lead to the development of novel therapies with greater and more specific anti-inflammatory effects.

Subjects

INFLAMMATORY mediators; EOSINOPHILS; ANTIHISTAMINES; IMIDAZOLES; THERAPEUTICS; MEDICAL research

Publication

Clinical & Experimental Allergy, 1994, Vol 24, Issue 1, p81

ISSN

0954-7894

Publication type

Academic Journal

DOI

10.1111/j.1365-2222.1994.tb00921.x