Title

THE INHIBITION OF CATALASE BY ASCORBIC ACID.

Authors

Foulkes, E. C.; Lemberg, R.

Abstract

The ascorbic acid inhibition of catalase is partly reversed by carbon monoxide, by low concentrations of diethyldithiocarbamate, and by high concentrations of phosphate. The inhibition is increased by the addition of copper, and is decreased in solutions with reduced copper content. It is concluded that the presence of copper is required for ascorbic acid inhibition of catalase. There is no evidence for the formation of ferrous catalase in the presence of ascorbic acid and low concentrations of hydrogen peroxide. Possible mechanisms of the inhibition are discussed.

Subjects

CATALASE; VITAMIN C; DIETHYLDITHIOCARBAMATE; HYDROGEN peroxide; CARBON monoxide

Publication

Australian Journal of Experimental Biology & Medical Science, 1948, Vol 26, Issue 4, p307

ISSN

0004-945X

Publication type

Academic Journal

DOI

10.1038/icb.1948.32