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Title

Characterization of Liver Regeneration Stimulatory Factor in Human Portal Serum.

Authors

Kubo, Shoji; Matsui-Yuasa, Isao; Otani, Shuzo; Morisawa, Seiji; Kinoshita, Hiroaki; Sakai, Katsuji

Abstract

Factors capable of stimulating DNA synthesis in rat hepatocytes (stimulating activity) were detected in the portal serum of patients after liver resection. The stimulatory factors were fractionated by gel filtration into four fractions with the molecular weights of 45,000-60,000 (fraction A), 1,500-2,500 (fraction B), 800-900 (fraction C), and about 700 (fraction D). Fraction A was inactivated by trypsin digestion or by being heated at 56°C for 2 h, suggesting that this factor might be a protein. The stimulating activity in fractions B, C, and D was dose-dependent. These stimulator/ factors seemed to be different from known hormones such as insulin and glucagon.

Subjects

DNA synthesis; LABORATORY rats; LIVER cells; SERUM; LIVER regeneration; LIVER surgery; INSULIN; GLUCAGON

Publication

American Journal of Gastroenterology (Springer Nature), 1988, Vol 83, Issue 10, p1103

ISSN

0002-9270

Publication type

Academic Journal

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