Title

Liver Cell Regeneration and Degeneration After Lobar Biliary Obstruction in Dogs.

Authors

Swanson Jr., Ernest A.; Millians, W. Swanson; Sotus, Peter C.; Skandalakis, John E.; Gray, Stephen W.

Abstract

1. With ligation of the hepatic duct from one lobe of the liver in the dog, typical degenerative changes are observed in the ligated lobe after 120 days. 2. Ilistochemical sections, stained for the enzyme 5-nucleotidase showed moderate enzyme activity in the normal liver and in the nonligated lobe of the experimental liver. In the ligated lobe the enzyme activity of the surviving hepatic cells was greatly increased. This increase is probably due to increased cell destruction in the ligated lobe. 3. While some mitoses arc present in the normal liver, mitotic indices rose to twice normal in the ligated lobe and to four times normal in the nonligated lobes.

Subjects

LIGATURE (Surgery); LIVER; LABORATORY dogs; ENZYMES; LIVER cells; MITOSIS

Publication

American Journal of Gastroenterology (Springer Nature), 1967, Vol 47, Issue 4, p280

ISSN

0002-9270

Publication type

Academic Journal