Title

Withania somnifera extract improves cognitive, behavioral and mood disorders in animal model of bipolar disorder.

Authors

IQBAL, Mohammad Rashid; SHARMA, Satish Kumar

Abstract

In this paper we examined the Withania somnifera extract (WSE) improve cognitive, behavioral and mood disorder in animal model of bipolar disorder. The present study was undertaken to investigate cognitive, behavioral and mood disorder effects of WSE on bipolar disorder of the male/female Wistar albino rats' brain. We have observed after 24 hours of last dosing the behavioral, memory and test were carried out followed by estimation of markers of oxidative stress under six groups using continuous sub-anesthetic dose of Amphetamine (Amph) (1.5 mg/kg, i.p) with WSE (300 mg/kg, i.p) and LiCl (1.5 mEq/kg, i.p.) administered daily for 21 days. We have found the percentage alteration was decreased in rat treated with WSE as compared to control indicate that it also improved spatial memory and learning. We have examined various oxidative parameters such as levels of SOD, GSH and TBARS level as compared to control groups. The reduced level of oxidative stress parameters upon administration of WSE and LiCl indicates ameliorating effects of WSE in oxidative stress. We had concluded that WSE showed improvement in learning and memory as animal treated with WSE spent more time in open arm as compared to Amph with WSE and LiCl treated rats. Hence, we can say that WSE improve cognitive, behavioral and mood disorder in animal model of bipolar disorder.

Subjects

AFFECTIVE disorders; BIPOLAR disorder; ANIMAL models in research; ANIMAL memory; BACOPA monnieri; LEARNING in animals; WITHANIA somnifera; ARIPIPRAZOLE

Publication

Journal of Research in Pharmacy, 2022, Vol 26, Issue 6, p1825

ISSN

2630-6344

Publication type

Academic Journal

DOI

10.29228/jrp.273