Title

EVALUATION THE EFFECT AND EFFICACY OF LIDOCAINE ON HEALING OF SKIN WOUND IN RABBITS.

Authors

Shekho, Hiba Abdulaziz; Wadee, Siham Agmee; Khorsheed Al-bayati, Hassan H.; Ismaeal, Maythaem A.

Abstract

The current study proceeded on six female rabbits weighing 1600 ± 200 g were used to determine the efficacy of 2% lidocaine (most commonly used concentration) in healing of skin wound. After anesthetized a two full thickness surgical incision were made on two sides of midline in back region of all animals, and divided into two groups randomly. In treated group, the right side were infiltrated with 3 ml of 2% lidocaine; In control group, the left side were infiltrated with 3ml of normal saline. Sites of intervention were estimated by histopathology. This study evidence 2% lidocaine that delay wound healing process and decrease wound strength, formation of blood vessel and other skin content as hair follicle and there muscle.

Subjects

HEALING; LIDOCAINE; SURGICAL site; HAIR follicles; HEMATOPOIESIS

Publication

Systematic Reviews in Pharmacy, 2020, Vol 11, Issue 12, p1368

ISSN

0975-8453

Publication type

Academic Journal