In vivo antioxidative activities of ellagic acid in indomethacin-induced gastric injury related oxidative stress.

KÜKÜRT, Abdulsamed

High-dose and/or long-term use of non-steroidal anti-inflammatory drugs is known to cause damage to the gastrointestinal tract and stimulate the production of reactive oxygen species (ROS) (McCarthy 1995, Vaish et al. 2013). The amount of ROS produced should be balanced with the antioxidant system in the cell. If the increase in the ROS level cannot be balanced, it may cause oxidative stress, which has an important role in the pathophysiology of diseases (Kükürt 2020, Kükürt et al. 2020, 2021). Ellagic acid is an effective natural herbal phenolic compound with free radical scavenging and antioxidant effects (Ippoushi et al. 2009). In this study, it was investigated that the effect of ellagic acid on total oxidant/antioxidant levels in gastric damage induced by indomethacin in mice. Twenty-eight male Swiss albino mice were divided into four equal groups as follows: Control, Indomethacin (25 mg/kg), Ellagic acid (10 mg/kg) and Indomethacin+Ellagic acid. The levels of plasma total antioxidant and oxidant capacity were analyzed by using a spectrophotometric method. I observed that indomethacin increased the total oxidant capacity levels. In addition, it has been observed that ellagic acid has an antioxidant effect. It was observed that ellagic acid had a protective effect against oxidative stress in the indomethacin + ellagic acid group. As a result, it was seen that ellagic acid had a protective effect against the oxidative stress caused by indomethacin. It was concluded that ellagic acid can be used as a therapeutic and protective agent in cases that cause oxidative stress due to its antioxidant properties.

ELLAGIC acid; GASTRIC acid; OXIDANT status; OXIDATIVE stress; REACTIVE oxygen species; LABORATORY mice

Journal of Cellular Neuroscience & Oxidative Stress, 2021, Vol 13, p16

2149-7222

Academic Journal