Delivery of Protein and Peptide by Oral Route.

PANDEY, ANSHUL; SON, SHASHANK

The protein and peptide is important material of living system and biological cell. It has hormones, enzymes, structural elements and immunoglobulin's .The distinction between peptides and proteins are peptide contains less than 20 amino acids, having a molecular weight less than 5000, while a protein possesses 50 or more amino acids and its molecular weight lies above this value. The most of pharmaceutical proteins and peptides are absorbed intramuscular route, intravenous route and subcutaneous route of Absorption, but the oral route is more convenient for absorption of protein as compared to other. Various problems associated with administration of protein and peptide drugs are needed to overcome by different pharmaceutical approaches. Several approaches available for maximizing pharmacokinetic and pharmacodynamics properties are chemical modification, formulation vehicles, mucoadhesive polymeric system, use of enzyme inhibitors, absorption enhancers, penetration enhancers etc.

PEPTIDES; IMMUNOGLOBULINS; PHARMACODYNAMICS; PHARMACOKINETICS; ENZYME inhibitors

International Journal of Pharmaceutical Research (09752366), 2021, Vol 13, Issue 3, p1182

0975-2366

Academic Journal

10.31838/ijpr/2021.13.03.026