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Title

Hyperinsulinemia and Insulin Resistance in Newly Detected Non-Diabetic Hypertensives.

Authors

Dalai, Siba Prasad; Sahu, Samir; Sahoo, Nalinikanta; Sohail; Mobin, Siddique Anam Mohd

Abstract

Background: Hypertension is one of the most important cause of increased morbidity and mortality across the world and India alike. Research into newer pathophysiologic mechanisms such as hyperinsulinemia and Insulin resistance independent of obesity needs to be carried out extensively to address these potential therapeutic areas. Purpose: To measure the serum insulin levels and levels of insulin resistance in newly detected hypertensive patients and to check for any possible correlation between grades of hypertension and levels of insulin resistance. Material and Methods: 100 newly detected hypertensive cases and 100 age and sex matched normotensive controls were included in our study over 2 years at our hospital in Bhubaneswar. Results: The study revealed that newly detected hypertensive cases had higher mean serum fasting insulin levels and higher Insulin resistance as calculated by HOMA2-IR model as compared to controls (p<0.001). Conclusion: It was found in our study that there was a statistically significant increase in values of serum fasting insulin levels and Insulin resistance (HOMA2-IR) with severity (grades) of hypertension.

Subjects

BHUBANESWAR (India); INDIA; INSULIN resistance; HYPERINSULINISM; HYPERTENSION; TYPE 2 diabetes; INSULIN; ESSENTIAL hypertension

Publication

JK Science, 2020, Vol 22, Issue 4, p181

ISSN

0972-1177

Publication type

Academic Journal

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