THE MICROBIOTA-GUT-BRAIN AXIS - A COMPLEX SYSTEM CROSS-TALK.

IEκANU, MARA IOANA; ZAHIU, CARMEN-DENISE-MIHAELA; GEORGESCU, IOANA ANTOANETA; ZĂGREAN, LEON; ZĂGREAN, ANA-MARIA

There is growing evidence suggesting a bidirectional interaction between the central nervous system, the enteric nervous system, and the gastrointestinal tract. Recent studies show that a pivotal factor for these gut-brain interactions is the gut microbiota. The microbiome was recently associated with modulation of behavior, cognition, and mental health. Multiple mechanisms, including nervous, endocrine, immune, and metabolic pathways are involved in the gut microbiota-brain axis, and conversely, the brain can also regulate the gut microenvironment. A more thorough understanding of the relationship between gut microbiota and the brain could advance our knowledge about the physiopathology of neurological diseases and help identify new target therapies via modulation of the microbiome.

ENTERIC nervous system; CENTRAL nervous system; GASTROINTESTINAL system; NEUROLOGICAL disorders; AUTONOMIC nervous system; PSYCHONEUROIMMUNOLOGY

Physiology / Fiziologia, 2020, Vol 30, Issue 1, p27

1223-2076

Academic Journal