Title

Isoorientin Alleviates Inflammatory Bowel Disease by Inhibiting NLRP3 Inflammasome Activation through Nrf2/NQO1 Pathway.

Authors

Qirun Cheng; Xianjin Yu; Rong Zhang; Lipeng Chen

Abstract

Inflammatory bowel disease comprises a series of related conditions characterized by idiopathic inflammation of the gastrointestinal tract. To develop therapeutic agents to combat these conditions, a better understanding of the inflammatory mechanisms is of paramount importance. Isoorientin is a c-glycosylflavone common to plants such as Phyllostachys japonicus and buckwheat. While it has been documented to exhibit multiple biological activities, its effects on inflammatory bowel disease, and the potential regulatory mechanism remain to be explored. We have shown here that isoorientin relieves the intestinal tissue injury and decreases the activity and expression of myeloperoxidase in trinitrobenzene sulfonic acid-exposed rats. Furthermore, isoorientin alleviated cytokine secretion in rats after trinitrobenzene sulfonic acid exposure. Also, isoorientin suppressed the levels of the nucleotide-binding domain and leucine-rich repeat-containing protein family and enhanced the Nrf2/NQO1 pathway in trinitrobenzene sulfonic acid-induced bowel disease. In conclusion, isoorientin could serve as a promising drug for the treatment of chronic enteritis.

Subjects

ACIDS; ANIMAL experimentation; CELLULAR signal transduction; CYTOKINES; ENZYME-linked immunosorbent assay; GENE expression; INFLAMMATORY bowel diseases; LEUCINE; MEDICINAL plants; NUCLEOTIDES; OXIDOREDUCTASES; RATS; WESTERN immunoblotting; DATA analysis software; FLAVONES; DESCRIPTIVE statistics

Publication

Current Topics in Nutraceutical Research, 2020, Vol 18, Issue 4, p392

ISSN

1540-7535

Publication type

Academic Journal

DOI

10.37290/ctnr2641-452X.18:392–397