Title

Hallmarks of cancer stem cells in men associated cancers: a review.

Authors

Surampudi, Sreedhar; Swamy, Satyanarayana; Rentala, Satyanarayana; Darsi, Sivarama Prasad

Abstract

Failure of conventional therapies is the root cause for the progression of cancer. Intrinsic revelation states that Cancer metastasis is due to subclonal diversification of normal cells into subsets of stem-like cells. These cells can be termed as stem cells of cancer or cells that initiate cancer. These diversified cells can differentially activate and escape from the resistant mechanisms causes tumor heterogeneity. Because of these metastatic fuelling which is malignant, it expresses its persistence towards treatment and provokes drugresistant recurrence. Annihilation of these subsets of stem-like cells in cancer tissues has now become a prime objective to develop and design novel classes of anti-cancer therapeutics to improve clinical efficacy. In this review, the properties and hallmarks of different cancer stem cells that are responsible for disease recurrence and metastases which are elusive targets for present oncotherapies were presented.

Subjects

CANCER stem cells; METASTASIS; DISEASE relapse; CANCER cells; CANCER in men

Publication

Onkologia i Radioterapia, 2020, Issue 1, p1

ISSN

1896-8961

Publication type

Academic Journal