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- Title
اثر سمیت عصاره هیدرو الکلی پوست پس ته و فرم لیپوزومی آن بر رده سلولهاي (HepG سرطانی کبد (2
- Authors
Harandi, H.; Majd, A.; Falahati-Pour, S. Khanamani; Mahmoodi, M.
- Abstract
Background and Objectives: Pistachio skin is rich in phenolic compounds and an inexpensive source of antioxidants, which can be a good option for combating cancer cells. The aim of this study was to determine the potential of pistacia vera hydroalcoholic extract and its liposomal form as a potential cytotoxic agent in HepG2 cell line, which is related to human liver cancer. Materials and Methods: In this in vitro study, the inhibitory effects of pistachio hull extract and its liposomal form on HepG2 and L929 cells were determined by the method of 3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium (MTT) at the concentrations of 0 to 4 mg / ml in 24 and 48 hrs, and for each cell line, the survival mean of the cells was analyzed using Dunnett's test.. Results: The results of this study showed that the hydroalcoholic extract of pistachio skin reduced the survival of liver cancer cells (HepG2) and decreased the cell viability by increasing time and concentration. Also, the results of the liposomal form of the extract showed that the liposomal extract reduced the survival of liver cancer cells (HepG2). Conclusion: The findings of this study indicated that the extract was more slowly released in the liposomal form than the free extract. Also in the liposomal form of the extract, the extract showed a lower toxicity to healthy L929 cells than liver cancer cells (HepG2).
- Subjects
LIVER cancer; LIPOSOMES; PISTACHIO
- Publication
Journal of Rafsanjan University of Medical Sciences, 2020, Vol 18, Issue 10, p1035
- ISSN
1735-3165
- Publication type
Academic Journal