The Effectiveness of the Use of Propolis toward the Number of Polymorphonucleas Cells in Mice Wounds.

Horax, Shaerly; Achmad, Harun; Dewi, Nurmala

Background: Propolis is a honey bee product with a very complex chemical composition, made by gummy and balsamic materials collected by bees from sprouts, flower buds, trees and other vegetal-tissue resinous trees. Propolis is useful as an antibacterial, antifungal and anti-inflammatory. During inflammation, polymorphonuclear migration to the wound area increases and propolis acts to suppress the amount of polymorphonuclear in the wound. Objective: To know the effectiveness of propolis to decrease the migration of polymorphouclear neutrophil cells to the wound in mice. Method: Experimental research with post-test only design with group control design. Propolis taken from the forest then made an extract with a concentration of 80% and then the mice were inserted with a wound depth of 2 mm and a wound length of 15 mm. Cut wounds of mice smeared with 80% propolis extract twice a day and then sacrificed 3 mice for check-up on days 1, 3, 5, and 7. Then histology was examined. Statistical analysis was performed by Mann Whitney test. Results: There were significant differences between treatment groups and control groups. Conclusion: Propolis extract with 80% concentration has an influence on suppressing the amount of polymorphonuclear migration to the inflammatory area.

PROPOLIS; BEE products; HONEYBEES; WOUNDS & injuries; MICE

Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 10, p1966

0976-0245

Academic Journal

10.5958/0976-5506.2019.03135.8