Title

Role of Kaempferol in decreasing 1-Methyl-4-phenylpyridinium induced mitochondrial dysfunction in sh-sy5y cells.

Authors

Choudhary, Apurva; Priya, V. Vishnu; Gayathri, R.

Abstract

Background: Kaempferol is a polyphenol antioxidant found in fruits and vegetables.1-Methyl-4-phenylpyridinium (MPP ) is a neurotoxin used in cellular models of Parkinson's Diseases. Several studies show that mitochondrial dysfunction is associated with early events in the pathogenesis of aging related neurodegenerative disorders including Parkinson's disease and Alzheimer's disease. The aim of the study is to analyze the role of kaempferol in decreasing the MPP -induced mitochondrial dysfunction in SH-SY5Y cells. Materials and Methods: The Role of Kaempferol in decreasing 1-Methyl-4- phenylpyridinium induced mitochondrial dysfunction was analysed using sh-sy5y cell lines. Results and Discussion: The role of kaempferol in protecting the SHSY5Y cells from MPP induced mitochondrial dysfunction was studied.

Subjects

ALZHEIMER'S disease; PARKINSON'S disease; CELL lines; NEURODEGENERATION; CELLS

Publication

Drug Invention Today, 2019, Vol 12, Issue 7, p1352

ISSN

0975-7619

Publication type

Academic Journal