Title

Syzygium polyanthum (Wight) Walp. leaves extract as the antifungal agent for oral candidiasis.

Authors

Kusuma, Sri Agung Fitri; Purnamasari, Evi; Herawati, Irma Erika

Abstract

Aim: The aim of this study was purposed to investigate the antifungal activity of Syzygium polyanthum (Wight) Walp. leaves extract against Candida albicans as natural antioral candidiasis (OC) candidate. Materials and Methods: The secondary metabolites content of S. polyanthum was detected by Harborne standard method. Ethanolic leaves extract at concentrations of 20, 40, 60, and 80% w/v was tested for the antifungal activity using the agar diffusion method. The minimum inhibitory concentration (MIC) value was determined as the lowest concentration that completely inhibited fungal growth using macrodilution method. For minimum fungicidal concentration (MFC) determination, a volume of liquid was taken from each tube that showed no fungal growth, then subcultured onto the surface of Sabouraud dextrose agar (SDA) medium. Results and Discussion: The phytochemical analysis of S. polyanthum exhibited the presence of total flavonoids and tannins. The antifungal activity of the extract exhibited a significant increasing of inhibitory diameters as the increasing of extract concentration. This statement correlated with the finding of MIC and MBC value of the extract in the low concentration range that of 0.1562-0.3125% w/v. Conclusion: The antifungal potent of S. polyanthum (Wight) Walp. leaves extract could give an important contribution in the treatment of OC caused by C. albicans.

Subjects

PHYTOCHEMICALS; ANTIFUNGAL agents; THRUSH (Mouth disease); SYZYGIUM; LEAVES; FUNGAL growth

Publication

Drug Invention Today, 2019, Vol 12, Issue 7, p1339

ISSN

0975-7619

Publication type

Academic Journal