Title

The effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity.

Authors

Kısadere, İhsan; Dönmez, Nurcan

Abstract

Aim: The aim of this study was to determine the effects of quercetin on antioxidant system and some blood parameters in rats exposed to acute cadmium toxicity. Materials and Methods: Adult male "Wistar-Albino" rats (n = 30) were used and divided into four groups as Control (C, n = 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium Quercetin (Cd Q, n = 8). Cadmium chloride (CdCl2, 4 mg/kg daily, s.c) were administrated to Cd and Cd Q groups, and Quercetin (Q, 50 mg/kg daily, i.p) were given to Q and Cd Q groups for 3 days, respectively. Control group was not recieved any treatment. Blood samples were collected from all animals at fourth day after treatments. Results: The levels of serum SOD, MDA, GSH, catalase, and plasma ALT, AST, GGT, total protein, albumin were detected. Although, serum MDA levels were found higher (P< 0.05) in Cd than the other groups, it was similiar in Q and C groups. ALT, AST and GGT enzyme levels were observed higher in Cd than C and Q groups (P< 0.05).. Conclusion: Negative effects of acute cadmium toxicity on antioxidan system and some hematological parameters were ameliorated with quercetin treatment in rats.

Subjects

QUERCETIN; CADMIUM; CADMIUM chloride; RATS; BLOOD; ANTIOXIDANTS

Publication

Eurasian Journal of Veterinary Sciences, 2019, Vol 35, Issue 2, p66

ISSN

1309-6958

Publication type

Academic Journal

DOI

10.15312/EurasianJVetSci.2019.225