Lupeol regulates glucose transporter-4 and AS160 in adipose tissue of high-fat diet-fed diabetic rats.

Devi, S. Kamala; Vishnpriya, V.; Ponnulakshmi, R.; Gayathri, R.; Shyamaladevi, B.; Madhan, K.; Pillai, Adithya R.; Selvaraj, J.

Background: Lupeol, a natural herbal drug, is abundant in edible vegetables, fruits, and also in medicinal plants. There are reports showing that lupeol can reduce hyperglycemia and hyperinsulinemia in experimental mice model. Objective: The objective of this study was to identify the effect of lupeol on glucose transporter (GLUT)-4 and AS160 protein expression in adipose tissue of high-fat diet and sucrose-induced Type-2 diabetic (T2D) rats. Materials and Methods: Lupeol was administered orally to T2D rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental animals was dissected out and used for the protein expression of GLUT-4 and AS160 in adipose tissue. Results: Lupeol treatment increased GLUT-4 protein level in the T2D animals. Conclusion: It is concluded from the present findings that lupeol has antihyperglycemic activity through the regulation of insulin signaling molecules (GLUT-4 and AS160). Hence, lupeol can be used as one of the therapeutic agents for the management of T2D.

ADIPOSE tissues; GLUCOSE; HIGH-fat diet; GLUCOSE transporters; INSULIN regulation; RATS

Drug Invention Today, 2019, Vol 12, Issue 6, p1188

0975-7619

Academic Journal