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Title: Assessment of intracellular calcium ion levels in neuroblastoma cells on treatment with kaempferol.
Authors: Jibu, Ritya Mary; Priya, V. Vishnu; Gayathri, R.
Abstract: Background: The neuroblast is a primitive nerve cell which does not undergo further division as it is a postmitotic cell. After the migration phase, it develops into a neuron. Materials and Methods: Cell culture – SHSY5Y cells were cultured and maintained in a prescribed medium. Cell treatment – the cells were pretreated with different concentrations of kaempferol for 4 h and then incubated with MPP for 2 h. Results and Conclusion: The intracellular calcium was significantly decreased at different dose levels, respectively. Kaempferol exhibits the good neuroprotective effect against MPP -induced toxicity to SHSY5Y cells, but it expresses the significant decrease in MPP -induced calcium production. Kaempferol was found to be an effective neuroprotective agent.
Subjects: CALCIUM ions; INTRACELLULAR calcium; THERAPEUTICS; NEURONS; CELL culture
Publication: Drug Invention Today, 2019, Vol 12, Issue 6, p1323
ISSN: 0975-7619
Publication type: Academic Journal

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Assessment of intracellular calcium ion levels in neuroblastoma cells on treatment with kaempferol.