Effect of lupeol on enzymatic and non-enzymatic antioxidants in type-2 diabetic adult male Wistar rats.

Pushpanjali, G.; Vishnupriya, V.; Ponnulakshmi, R.; Gayathri, R.; Madhan, K.; Shyamaladevi, B.; Selvaraj, J.

Background: Lupeol is a pharmacologically active triterpenoid found in mango and variety of medicinal plants including Acacia visco and Abronia villosa. It is also found in dandelion coffee. Many scientific studies have shown that lupeol possesses many beneficial pharmacological activities including anti-inflammatory, antioxidant, and antihyperglycemic activity. Biomarkers for oxidative damage to DNA, lipids, and proteins are also supporting the concept of increased oxidative stress in diabetes and diabetic nephropathy. In the present study, we elucidated the antioxidant potential of lupeol by analyzing the enzymic and non-enzymic antioxidant in the liver of high-fat diet and sucrose-induced type-2 diabetic rats. Objectives: The study aimed to identify the effects of lupeol on enzymic antioxidants superoxide dismutase (SOD), catalase (CAT), and non-enzymic antioxidant (Vitamin C) in the liver of high-fat diet and sucrose-induced type-2 diabetic adult male rats. Methodology: Lupeol was administered orally to type-2 diabetic rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental rats dissected out and the used for the studied. Results: There was a marked decrease observed in the levels of antioxidant enzymes (SOD, CAT, and Vitamin C) in the liver of the type-2 diabetic rats. However, lupeol treatment efficiently increased the level of antioxidant enzymes compared to diabetic group. Metformin showed a similar pattern to that of lupeol. Conclusion: The present finding concluded that the lupeol regulates antioxidant enzymes, and hence, it can be used for the management of type-2 diabetes as a natural compound.

STREPTOZOTOCIN; DNA damage; HIGH-fat diet; SUPEROXIDE dismutase; VITAMIN C; RATS

Drug Invention Today, 2019, Vol 12, Issue 5, p873

0975-7619

Academic Journal