Lupeol supplementation attenuates overexpression of sterol regulatory element-binding protein in hepatocytes: An experimental study.

Jayavabhushana, V.; Vishnupriya, V.; Ponnulakshmi, R.; Gayathri, R.; Shyamaladevi, B.; Madhan, K.; Selvaraj, J.

Background: Lupeol, a natural herbal drug, is abundant in edible vegetables, fruits, and also medicinal plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of lupeol on sterol regulatory element, binding protein (SREBP-1c) in hepatocytes is not known. Objectives: The study aimed to identify the effects of lupeol on SREBP-1c protein expression in liver tissue of type 2 diabetic rats. Methods: Lupeol was administered orally to type 2 diabetic rats (25 mg/kg body weight) for 30 days. After the treatment period, animals were anesthetized and the liver from control and experimental animals was dissected out and used for the protein expression of SREBP-1c. Results: In type 2 diabetic animals, the protein expression of SREBP-1c was found to be elevated in high-fat diet-induced type 2 diabetic rats when compared with control. The lupeol administration to diabetic rats reduced the SREBP-1c protein expression due to its antioxidant potentials. Conclusion: Our present finding indicates that the antidiabetic activity of lupeol in the liver is mediated through the attenuation of SREBP-1c protein.

STEROL regulatory element-binding proteins; STREPTOZOTOCIN; PROTEIN expression; PROTEIN binding

Drug Invention Today, 2019, Vol 12, Issue 5, p866

0975-7619

Academic Journal