Lupeol supplementation to high-fat diet-fed type-2 diabetic rats alleviates hepatic lipid profiles.

Kowshihan, P.; Selvaraj, J.; Vishnpriya, V.; Ponnulakshmi, R.; Gayathri, B.; Madhan, K.; Shyamaladevi, B.

Background: Lupeol, a natural herbal drug is abundant in edible vegetables, fruits, and also in medicinal plants. It has been shown to reduce hyperglycemia and hyper insulinemia in experimental mice model. Despite, the effect of lupeol supplementation to high-fat diet-fed type-2 diabetic rats alleviates hepatic lipid profiles is not known. Objectives: The study aimed to identify the effects of lupeol on hepatic lipid profiles expression in liver tissue of type-2 diabetic rats. Methodology: Lupeol was administered orally to type-2 diabetic rats (25 mg/kg body weight) for 30 days. After the treatment period, animals were anesthetized, and liver from control and experimental animals were dissected out and used for the hepatic lipid profiles. Results: Diabetic rats showed a significant increase in the levels of serum total cholesterol, triglyceride, low-density lipoprotein cholesterol cholesterol, very low-density lipoprotein cholesterol, and free fatty acids, but a significant decrease in high-density lipoproteins cholesterol level, whereas lupeol treatment reversed the same effectively Conclusion: Our present finding indicates that the antidiabetic activity of lupeol in the liver is mediated through the alleviates hepatic lipid profiles.

STREPTOZOTOCIN; FREE fatty acids; BLOOD cholesterol; LIPIDS; RATS; LABORATORY animals

Drug Invention Today, 2019, Vol 12, Issue 4, p785

0975-7619

Academic Journal