The Effect of Different Doses of Ellagic Acid on the Serum Lipid Profile and Total Antioxidant of Rat.

AKKUŞ, Songül; DEĞER, Yeter

This study was planned to determine in which dose of ellagic acid it shows the optimum effect on lipid, lipoprotein and total antioxidant capacity. For this purpose, 40 male rats (Wistar-albino) weighing 200-250 g were used. Control, group 1 (EA 3 mg/kg), group 2 (EA 10 mg/kg), group 3 (EA 12 mg/kg) and group 4 (EA 20 mg/kg) were designated, each containing 8 rats. Following orally application of ellagic acid (EA) every other day for eight weeks, from the blood samples taken; the measurement of triglyceride, cholesterol, LDL and HDL were determined by modular auto-analyzer using commercial kit. VLDL levels were calculated by formula. The total antioxidant capacity (TAS) was measured through spectrophotometer using the commercial kit. When compared with the control group, it was found that while TAS, triglyceride, HDL and VLDL levels were increased, LDL and cholesterol levels were decreased in the all EA applied groups. These changes weren't important statistically (P=0.05). Consequently, with regard to the data acquired in this study, it is recommended that in further research, the protective dose of ellagic acid is higher than 20 mg/kg/day and prolonged use.

Van Veterinary Journal, 2017, Vol 28, Issue 3, p127

2149-3359

Academic Journal