Relationship between serum caspase-1 levels, insulin resistance and oxidative stress in women with polycystic ovary syndrome.

CABUŞ, Ümit; FENKÇI, Semin; FENKÇI, Veysel; CANER, Vildan; ENLI, Yaşar

Caspase-1 is implicated in several important inflammatory diseases including polycystic ovary syndrome (PCOS). Interleukin-10 (IL-10) is an antiinflammatory cytokine and plays important role in chronic inflammatory conditions. This study was planned to determine Caspase-1 and IL-10 levels in women with PCOS. Forty-two women with PCOS and thirty-seven healthy controls were evaluated in this controlled clinical study. Serum lipid sub-fractions, fasting glucose, insulin and other hormones (gonadotropins, androgens), IL-10, malondialdehyde (MDA), glutathione (GSH) and Caspase-1 levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance. Free androgen index (FAI), HOMA-IR, MDA and Caspase-1 levels were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower GSH concentrations levels than healthy subjects. Serum IL-10 levels were higher in study subjects than in controls, although it was statistically insignificant. Caspase-1 was positively associated with IL-10. These outcomes propose that Caspase-1 may have a pivotal role in triggering the processes leading to chronic low-grade inflammation in the pathogenesis of PCOS, independent of insulin resistance, androgen excess and oxidative stress. Nevertheless, the precise role of Caspase-1 in the pathogenesis of the disease remains to be elucidated.

OXIDATIVE stress; POLYCYSTIC ovary syndrome; INSULIN resistance; CYTOKINES; METABOLIC syndrome

Journal of Cellular Neuroscience & Oxidative Stress, 2018, Vol 10, Issue 2, p727

2149-7222

Academic Journal