Title

PPARα activation: a drink from the fountain of youth?

Authors

Poynter, Matthew E.; Daynes, Raymond A.

Abstract

This article focuses on ageing and strengthening aged immune system. Age-associated reductions in circulating levels of peroxisome proliferator activated receptor α(PPARα) activators such as dehydroepiandrosterone-3β-sulphate (DHEAS) may compromise normal cellular responses that involve PPARα activation, thereby hindering the essential maintenance of cellular redox balance. Supplementing aged mice with PPARα activators has proven to be helpful in re-establishing cellular redox balance, thereby promoting the reacquisition of immune competence and possibly alleviating a number of age-associated pathophysiologies.

Subjects

AGING; IMMUNE system; DEHYDROEPIANDROSTERONE; ADRENOCORTICAL hormones; PEROXISOMES; PATHOLOGICAL physiology

Publication

Biologist, 2004, Vol 51, Issue 1, p27

ISSN

0006-3347

Publication type

Periodical