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Title: Oleanolic acid saponins from Monoammonium glycyrrhinate and their NO inhibition activity.
Authors: Qiang Ren; Ming Bai; Qin Li; Guodong Yao; Xiaoxiao Huang; Shaojiang Song
Abstract: Six oleanolic acid saponins were isolated from Monoammonium glycyrrhinate (MAG). Their structures were elucidated via spectroscopic data analyses, including 13C NMR and HRESIMS. The assay concerning the inhibition of NO inhibition induced by lipopolysaccharide in RAW 264.7 cells was conducted to evaluate their anti-inflammatory activity of the isolated triterpenoid saponins. The results revealed that compound 4 exhibited weak inhibitory activity on the production of NO with the inhibition rate 12.04% at 100 µM compared with the positive control drug, minocycline, the inhibition rate of which was 35.39% at 100 μM.
Subjects: SAPONINS; LIPOPOLYSACCHARIDES; ANTI-inflammatory agents; TRITERPENOID saponins; INHIBITION (Chemistry)
Publication: Asian Journal of Traditional Medicines, 2017, Vol 12, Issue 5, p210
ISSN: 1817-4337
Publication type: Academic Journal

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Oleanolic acid saponins from Monoammonium glycyrrhinate and their NO inhibition activity.