Title

In vivo and in vitro evaluation of the anti-diabetic nutraceutical potentials of Capparis spinosa.

Authors

Mollica, Adriano; Stefanucci, Azzurra; Macedonio, Giorgia; Locatelli, Marcello; Onaolapo, Olakunle; Onaolapo, Adejoke; Novellino, Ettore

Abstract

In this study, we investigated Capparis spinosa leaf and commercial salted buds. This was with the aim of evaluating its usefulness as a valuable nutraceutical. We conducted a series of in vivo and in vitro tests. The leaf, fresh buds and salty buds (desalted 24 h in water) were obtained and processed to dry powder. 40% MeOH/H2O extract was obtained for HPLC analysis, to determine quantitatively the polyphenols, flavonoids and the presence of other relevant compounds. The inhibition of enzymes related to different dismetabolic pathologies were also assessed. To evaluate the anti-diabetic potential in rodents, dry powder of Capparis Spinosa leaf and bud were administered orally to streptozocin-induced diabetic rats over a period of 21 days, during which body weight and blood glucose were monitored weekly. At the end of the experimental period, animals were sarificed and blood taken for assessment of lipid profile, and liver/kidney biochemistry.

Subjects

HYPOGLYCEMIC agents; FUNCTIONAL foods; CAPPARIS spinosa

Publication

Analele Ştiinţifice ale Universităţii 'Al.I. Cuza' din Iaşi. Secţiunea II a, Biologie Vegetală, 2016, Vol 62, Issue 1, p36

ISSN

1223-6578

Publication type

Academic Journal