Title

Antiviral activity of Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis against respiratory syncytial virus.

Authors

Agbo, Matthias Onyebuchi; Odimegwu, Damian Chukwu; Chiedu Okoye, Festus Basden; Osadebe, Patience Ogoamaka

Abstract

Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside. The antiviral activity of the isolated compound was evaluated against the respiratory syncytial virus. The isolated Salidroside showed potent inhibition towards a recombinant straining respiratory syncytial virus with Inhibitory Concentration (IC50) value of 10.3±1.50 μg/mL. The result indicates that Salidroside is an efficient antiviral agent against RSV infection and might be useful for the management of RSV pathogenesis.

Subjects

ANTIVIRAL agents; HEVEA; MISTLETOES; RNA virus infections; RUBBER plants; REPRODUCTION

Publication

Pakistan Journal of Pharmaceutical Sciences, 2017, Vol 30, Issue 4, p1251

ISSN

1011-601X

Publication type

Academic Journal