Title

GLUCOSE METABOLISM OF THE ISOLATED ECCRINE SWEAT GLAND. I. The Effects of Mecholyl, Epinephrine and Ouabain.

Authors

Sato, Kenzo; Dobson, Richard L.

Abstract

The effects of mecholyl, epinephrine and ouabain on glucose metabolism were studied in freshly dissected human and monkey paw eccrine sweat glands. Both showed active glycolytic activity which was further stimulated by mecholyl and epinephrine. Ouabain inhibited unstimulated as well as mecholyl or epinephrine-stimulated glycolysis and mecholyl-stimulated 14CO2 production. Anaerobic incubation and the addition of KCN markedly enhanced lactate production Mecholyl and lower concentrations of epinephrine stimulated both 14CO2 and lactate production. Higher concentrations of epinephrine stimulated lactate production but markedly suppressed 14CO2 production. A possible link between energy production and glandular secretion was discussed.

Subjects

SWEAT glands; GLUCOSE; CUTANEOUS glands; ADRENALINE; BRONCHODILATOR agents; MONKEYS

Publication

Journal of Investigative Dermatology, 1971, Vol 56, Issue 4, p272

ISSN

0022-202X

Publication type

Academic Journal

DOI

10.1111/1523-1747.ep12261004