Title

Effects of the Coreopsis tinctoria extracts on anti-aging in the aging model mice.

Authors

Weixin Zhang; Haiyan Hao; Ailong Sha

Abstract

The effects of the Coreopsis tinctoria extracts on anti-aging were observed by investigating the cerebral index and viscera indexes, the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the serums, the activities of glutathione peroxidase (GSH-Px) in the brain tissues and the ones of catalase (CAT) and superoxide dismutase (SOD) in the liver tissues of the aging model mice. The aging model mice were injected subcutaneously with D-galactose in vivo and intragastric administrated with the Coreopsis tinctoria extracts at doses of low (0.5g/kg), medium (1g/ kg) and high (2g/ kg) once daily for 6 weeks. The results showed that all the cerebral index, spleen index, thymus index, liver index and kidney index of the three groups dosed of the Coreopsis tinctoria extracts increased, the activities of GSH-Px in the brain tissues and the ones of CAT and SOD in the liver tissues increased to different degree while the contents of H2O2 and MDA in the serums decreased extremely and significantly (P<0.01) compared with the aging model mice. All of these results suggested that the Coreopsis tinctoria extracts might possess anti-aging effects by improving antioxidant capacity of the mice.

Subjects

COREOPSIS; AGING prevention; THERAPEUTIC use of plant extracts; GLUTATHIONE peroxidase; LABORATORY mice

Publication

Indian Journal of Animal Research, 2016, Vol 50, Issue 5, p769

ISSN

0367-6722

Publication type

Academic Journal

DOI

10.18805/ijar.9630