Title: Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine.
Authors: Zyuz'kov, G.; Zhdanov, V.; Udut, E.; Miroshnichenko, L.; Chaikovskii, A.; Simanina, E.; Polyakova, T.; Minakova, M.; Udut, V.; Tolstikova, T.; Shul'ts, E.; Stavrova, L.; Burmina, Ya.; Suslov, N.; Dygai, A.
Abstract: The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
Subjects: ALKALOIDS; CYTOLOGY; CYTOPROTECTION; EMBRYOLOGY; PROGENITOR cells
Publication: Bulletin of Experimental Biology & Medicine, 2015, Vol 159, Issue 5, p642
ISSN: 0007-4888
Publication type: Academic Journal
DOI: 10.1007/s10517-015-3036-0

Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine.

Zyuz'kov, G.; Zhdanov, V.; Udut, E.; Miroshnichenko, L.; Chaikovskii, A.; Simanina, E.; Polyakova, T.; Minakova, M.; Udut, V.; Tolstikova, T.; Shul'ts, E.; Stavrova, L.; Burmina, Ya.; Suslov, N.; Dygai, A.