Title

HEPATOPROTECTIVE ACTIVITY OF CARISSA CARANDAS LINN. FRUIT ETAHNOLIC EXTRACT IN CARBON TETRACHLORIDE INTOXICATED RATS.

Authors

Bodakhe, Surendra H.; Devi, Nirmala; Gupta, Sanjay K.; Namdeo, K. P.; Jain, S. K.

Abstract

To investigate hepatoprotective effect of ethanolic extract of Carissa carandas fruits in carbon tetrachloride intoxicated rats. Carissa carandus unripe fruits were collected, dried, powdered and subjected to extraction using ethanol as solvent. Wistar rats were divided into seven groups (n=6) and induced hepatotoxicity using carbon tetrachloride [CCl4 with Olive oil (1:1), 0.5 ml/kg, i.v.], administered for 5 days. Three different doses (100, 200 and 400mg/kg) of ethanolic extract of Carissa carandus (EECC) fruits were used to administer and improvement in liver function was observed by estimation of serum marker enzymes like aspartate amino transferase (AST), alanine amino transferase ( ALT), alkaline phosphatase (ALP), serum bilirubin (SBLN), gamma glutamyl transpeptidase (GGT), total lipids (TL), albumin etc. The normal values for AST, ALT, ALP, SBLN, GGT, TP, TL and albumin in serum were significantly altered in hepatotoxic rats. These parameters attained near normal values in EECC (100 & 200mg/kg) treated rats.

Subjects

HERBAL medicine; PLANT extracts; CARBON tetrachloride; FRUIT juices; ALCOHOLIC intoxication; THERAPEUTICS

Publication

Advances in Pharmacology & Toxicology, 2014, Vol 15, Issue 3, p51

ISSN

0973-2381

Publication type

Academic Journal