Title

Hepatoprotective activity of aqueous methanolic extract of Viola odorata against paracetamol paracetamol-induced liver injury in mice.

Authors

Qadir, M. Imran; Ali, Muhammad; Saleem, Mohammad; Hanif, Muhammad

Abstract

Traditionally Viola odorata is used for liver protection. To provide scientific support to its traditional use, aqueous methanolic extract of V. odorata (250 mg/kg and 500 mg/kg) was given to mice intoxicated with paracetamol. Obtained results demonstrated that the extract significantly (p<0.01-0.001) reduced paracetamol induced increase levels of serum hepatic enzymes and total bilirubin. Histopathological studies showed that the plant attenuated the hepatocellular necrosis and inflammation. HPLC results showed the presence of hepatoprotective flavonoids (isorhamnetin and luteolin) in the extract. It was concluded from the present study that V. odorata has hepatoprotective activity against paracetamol-induced liver injury in mice.

Subjects

VIOLACEAE; LIVER injuries; ACETAMINOPHEN; LIVER enzymes; PLANT extracts; LABORATORY mice; THERAPEUTICS

Publication

Bangladesh Journal of Pharmacology, 2014, Vol 9, Issue 2, p198

ISSN

1991-007X

Publication type

Academic Journal

DOI

10.3329/bjp.v9i2.18049