The Antioxidation of Proanthocyanidins from in Rhodiola rosea L.

GAO, Ying; HAO, Hongwei; LIU, Xinyu; LIU, Min; WANG, Weilin

[Objective] To discuss the antioxidation of proanthocyanidins (OPCRR) in Rhodiola rosea L. [Methods] By establishing peroxide injury model of ICR mice induced by D-gal, intragastric administration of mice was carried out for continuous 49 d. Then, 80, 160 and 320 (BW) mg/kg OPCRR were added into low-, middle- and high-dosage groups, respectively. The SOD, GSH, GSH-Px and MDA in serum, heart, liver and brain tissues and the MAO in liver and brain tissues were investigated. [Results] Compared with model control group, OPCRR at certain dosage could significantly enhance the SOD and GSH-Px activities of mice serum, heat, liver and brain tissues, and obviously reduced the MDA content. And high-dosage group was the most prominent. In high-dosage group, SOD activities of serum, heart, liver and brain tissues enhanced by 29. 5%, 28. 1%, 62. 7% and 90. 8%, respectively; GSH-Px activities enhanced by 67. 8%, 58.4%, 32. 1% and 50.3%, respectively; MDA contents reduced by 19.2%, 30.0%, 33.3% and 19.2%. Besides, middle- and high-dosage groups showed extremely significant effects on reducing the brain MAO activity (P < 0. 01), which decreased by 22. 3% and 28. 6%, respectively. High-dosage group significantly reduced the liver MAO activity (P < 0. 05) by 36. 5 % . [Conclusions] OPCRR protected the organism in different degrees, antagonized peroxidation injury induced by D-gal, and prevented from aging.

ANTIOXIDANTS; PROANTHOCYANIDINS; ROSEROOT; PEROXIDES; LABORATORY mice; SUPEROXIDE dismutase; MALONDIALDEHYDE; SERUM; THERAPEUTICS

Medicinal Plant, 2014, Vol 5, Issue 8, p8

2152-3924

Academic Journal