EBSCO Logo
Connecting you to content on EBSCOhost
Title

Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity.

Authors

Vakiloddin, Syed; Fuloria, Neeraj; Fuloria, Shivkanya; Dhanaraj, Sokkalingam Arumugam; Balaji, Kaveti; Karupiah, Sundram

Abstract

The objective of present study was to explore the hepatoprotective and antioxidant profile of Citrullus colocynthis fruits. Hepatoprotective profile of methanolic extract of Citrullus colocynthis fruits (MECCF) was investigated on rats, which were made hepatotoxic using paracetamol. The antioxidant profile of MECCF was evaluated by conducting Catalase, Super oxide Dismutase, Lipid Peroxidation and Diphenyl Picryl Hydrazyl tests. During hepatoprotective investigation, the Paracetamol treated group II showed significant increase in total bilirubin (TB), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) level. The results so obtained showed that pretreatment of rats with MECCF 300mg/kg p.o. decreases the elevated TB, SGOT, SGPT and ALP serum levels. Also, MECCF inhibitory profile was found comparable with toxicant group (Paracetamol 2g/kg, p.o.). The present study concludes that MECCF fruit possess significant hepatoprotective and antioxidant activity.

Subjects

ANTIOXIDANTS; CITRULLUS; ACETAMINOPHEN; HEPATOTOXICOLOGY; LIPID peroxidation (Biology); BLOOD serum analysis

Publication

Pakistan Journal of Pharmaceutical Sciences, 2015, Vol 28, Issue 3, p951

ISSN

1011-601X

Publication type

Academic Journal

EBSCO Connect | Privacy policy | Terms of use | Copyright | Manage my cookies
Journals | Subjects | Sitemap
© 2025 EBSCO Industries, Inc. All rights reserved