The hypolipidemic effect of artesunate and ursolic acid in rats.

Wang Yuliang; Wang Zejian; Shen Hanlin; Yin Ming; Tang Kexuan

To find the novel hypolipidemic agents, the effects of ursolic acid and artesunate on hyperlipidemia were determined in rats fed a Western-type diet developed a hyperlipidemia. Rats received ursolic acid (50 mg/kg) or artesunate (50 mg/kg) alone, or in combination (25 25 mg/kg and 50 50 mg/kg), to prevent hyperlipidemia. Ursolic acid or artesunate alone significantly decreased the plasma triglyceride, but had no effect on the levels of cholesterol. The combination of ursolic acid and artesunate can reduce both triglyceride and cholesterol, and the effects were more potent than either agent alone, which indicates a strong synergistic effect. The hypolipidemic effect of artesunate is firstly reported. Its combination with ursolic acid might have the potential to further develop for the treatment of hyperlipidemia.

HYPOLIPEMIA; URSOLIC acid; LABORATORY rats; DRUG development; DRUG efficacy; TRIGLYCERIDES

Pakistan Journal of Pharmaceutical Sciences, 2015, Vol 28, Issue 3, p871

1011-601X

Academic Journal