Title

Hormesis in cancer immunology.

Authors

Pearce, Oliver MT; Läubli, Heinz; Bui, Jack; Varki, Ajit

Abstract

We recently reported that tumor-directed antibodies could either stimulate, or inhibit, tumor progression, dependent upon the dosage used. The narrow range over which this immune response curve (IRC) occurs is surprising. Here we discuss features of the IRC, the mechanisms identified so far, and the potential clinical implications.

Subjects

HORMESIS; CANCER cells; CELLULAR immunity; CANCER invasiveness; IMMUNE response; IMMUNOTHERAPY

Publication

OncoImmunology, 2014, Vol 3, Issue 6, pN.PAG

ISSN

2162-4011

Publication type

Academic Journal

DOI

10.4161/onci.29312