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Title

Yoğun Bakım ünitelesinde Yatan Hastaların Kan Kültürlerinden İzole Edilen Acinetobacter baumannii SuŞlarında Antimikrobiyal Direnç.

Authors

ŞANAL, Laser; KILIÇ, Hasan

Abstract

Objective: Acinetobacters play an important role in the colonisation, urinary system infections, wound infections, pneumonia, bacteremia and meningitis, especially in immunosupressive patients hospitalized in intensive care units. In this study we aimed to determine the antibiotic resistance profiles of Acinetobacter baumannii(A.baumannii) strains isolated from blood cultures of inpatients in intensive care units. Material And Method: 100 A. baumannii strains were isolated from blood cultures of inpatients in various intensive care units between January 2012 and December 2013. The samples were inoculated onto Eosin Methylene Blue (EMB) Agar and 5% sheep blood agar. Conventional methods and automatised system (VITEK 2, bioMerieux, France) were both used to identify antibiotic susceptibilities of the strains. Results were evaluated according to recommendations of Clinical and Laboratory Standards Institute (CLSI). Results: Resistance rates of A. baumannii strains were as follows:, ampicillin/sulbactam 96%, trimethoprim/ sulfamethoxazole 64%, tetracycline 35%, netilmicin 12%, amikacin 44% , cefepime 94% , gentamicin 20%, piperacillin 96% ceftazidime 96%, tigecycline 13% piperacillin/tazobactam 96% , cefoperazone/sulbactam 66% , ciprofloxacin 89%, levofloxacin 92% , imipenem 94% , meropenem 94%. Colistin resistance was not detected in A. baumannii strains. After colistin, the highest in vitro activity was shown in netilmicin and tigecycline for isolated strains. Conclusion: The increasing resistance rates to many antibiotics, especially carbapenems are making the situation more serious and complicated in the treatment of infections caused by A.baumannii strains. Hospitals should develop their own antibiotic policies according to reistance patterns especially in ampiric therapy.

Publication

Ortadogu Medical Journal / Ortadogu Tip Dergisi, 2014, Vol 6, Issue 3, p105

ISSN

1309-3630

Publication type

Academic Journal