Correlation Between Aldosterone and Gestational Diabetes Mellitus.

LI Liping; LIU Jie; MA Yujin

Objective To analyze the relationship between plasma aldosterone level and gestational diabetes mellitus. Methods All subjects were divided into three groups (n=20 in each group): gestational diabetes mellitus (GDM) group, pregnancy with normal glucose group, non-pregnant healthy women group. Pre-pregnant body mass index (BMI) was calculated, and fasting blood glucose (FBG), blood lipid level, Fins, HOMA-IR index, RASS, PRA, ATIi and ALD were examined besides glucose intolerance test. Results The plasma ALD level was significantly higher in GDM group than that of NGT group and control group(pmol/L: 1 130.15±135.45 vs 1 053.98±108.86 vs 544.31±127.97). The plasma ALD level was positively correlated with FBG,c1 h PBG,2 hPBG, Fins, HOMA-IR and blood triglyceride (r=0.657, 0.757, 0.713, 0.429, P< 0.05), but negatively correlated with HDL-C (r=-0.267,P=0.039). Stepwise regression analysis revealed that plasma aldosterone was the independent risk factor of GDM. Conclusion RASS is excessively activated in pregnancy, which contributes to gestational diabetes mellitus.

ALDOSTERONE; GESTATIONAL diabetes; INSULIN resistance; PREGNANCY complications; BODY mass index

Tianjin Medical Journal, 2014, Vol 42, Issue 11, p1094

0253-9896

Academic Journal

10.3969/j.issn.0253-9896.2014.11.011