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- Title
EFFECTS OF CHLORELLA PYRENOIDOSA ON CUTANEOUS ARTERIAL SYMPATHETIC NERVE ACTIVITY, CUTANEOUS BLOOD FLOW AND TRANSEPIDERMAL WATER LOSS IN RATS.
- Authors
Yuko Horii; Tohru Mizoguchi; Yoshiyuki Fujisaki; Risa Fuyuki; Katsuya Nagai
- Abstract
Chlorella pyrenoidosa (C. pyrenoidosa) has higher content of chlorophyll than any known other plants, and also has vitamins, minerals, dietary fiber and other substances. To identify the effect of C. pyrenoidosa on skin condition, we measured cutaneous arterial sympathetic nerve activity (CASNA), cutaneous blood flow and transepidermal water loss (TEWL) in rats in three separate trials. We further attempted to determine if C. pyrenoidosa was targeting the histamine H3 receptors by pretreating a separate group with thioperamide, a histamine H3 antagonist, and then observing the CASNA and cutaneous blood flow response to C. pyrenoidosa in a fourth trial. Intraduodenal administration of C. pyrenoidosa caused marked inhibition of CASNA as well as significant elevation of cutaneous blood flow in rats. TEWL, furthermore, significantly decreased on the dorsal skin of conscious hairless rats when their only source of fluids was C. pyrenoidosa suspended in water. However, when animals were pretreated with thioperamide, C. pyrenoidosa eliminated the response of CASNA and cutaneous blood flow. These findings suggest that C. pyrenoidosa reduces CASNA, increases cutaneous blood flow, and enhances the water-retaining ability of the skin, and that histamine H3 receptors may be involved in the CASNA and cutaneous blood flow response.
- Subjects
CHLORELLA pyrenoidosa; SYMPATHETIC nervous system physiology; BLOOD flow; BLOOD supply to skin; BLOOD water; HISTAMINE
- Publication
Current Topics in Nutraceutical Research, 2014, Vol 12, Issue 3, p107
- ISSN
1540-7535
- Publication type
Academic Journal