EFFECT OF DAIDZEIN AND GENISTEIN ON SERUM GLUCOSE, LIPID PROFILE AND PAROXONASE ACTIVITY IN DIABETIC RATS.

Eftekhari, Mohammad Hassan; Honarvar, Niyaz Mohammadzadeh; Rajaeifard, Abdolreza; Owji, Aliakbar

Evidence is emerging that soybean phytoestrogens play a beneficial role in diabetes. This study was conducted to evaluate the effect of daidzein and genstein as most important isoflavones in soybean on glucose, lipid profile and antioxidant enzyme activities in diabetic rats. Sixty male Sprague-Dawley rats were divided into six equal groups. Experiments were performed for 21 days. The rats of Group A as healthy control and group B as diabetic control were fed laboratory standard diet. The rats of Groups C, D and E were fed standard laboratory diet plus 600 mg/ kg daidzein, 600 mg/kg genstein, and 600 mg/kg daidzein and genstein 50/50 respectively. Diabetes in groups B, C, D, and E was induced by a single injection of 60 mg/ kg body weight streptozotosin (STZ). Blood biochemical parameters such as serum glucose, T-Cholesterol, triglyceride (TG), LDL, HDL and Paraxonase activity were measured Daidzein and genistein showed a significant positive effects in ameliorating lipid profile in treatment groups. Administration of daidzein and genistein to the STZ-induced rats significantly increased paraxonase activity. our results indicate that supplementation diabetic rats with isoflavones was accompanied by an improvement in some indices of diabetes mellitus.

DAIDZEIN; GENISTEIN; BLOOD sugar; BLOOD lipids; PEOPLE with diabetes; LABORATORY rats; PHYTOESTROGENS

Current Topics in Nutraceutical Research, 2014, Vol 12, Issue 3, p85

1540-7535

Academic Journal