Works matching AU Wiebe, Leonard I.

Results: 46

CycloSaligenyl Pronucleotides of 5-Iodo and 5-Trifluoromethyl-1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluorobenzene Mimics of Thymidine:‡ Synthesis and Evaluation of this Pronucleotide Monophosphate Delivery System for Compounds with Potential Anticancer Activity#

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2003, v. 22, n. 12, p. 2121, doi. 10.1081/NCN-120026634

By:

Yan Sun, Wei;
Zhou, Aihua;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

Syntheses of 1-[(2-Hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-Propoxy)methyl]- Derivatives of 5-Substituted-2,4-difluorobenzene: Unnatural Acyclo Thymidine Mimics for Evaluation as Anticancer and Antiviral Agents.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2000, v. 19, n. 9, p. 1397, doi. 10.1080/15257770008033850

By:

Wang, Zhi-Xian;
Duan, Weili;
Wiebe, Leonard I.;
Clercq, Erik De;
Balzarini, Jan;
Knaus, Edward E.

Publication type:

Article

Imaging Tumor Hypoxia and Tumor Perfusion.

Published in:

Journal of Nuclear Medicine, 1993, v. 34, n. 6, p. 885

By:

Groshar, David;
McEwan, Alexander J. B.;
Parliament, Matthew B.;
Urtasun, Raul C.;
Golberg, Lon E.;
Hoskinson, Michael;
Mercer, John R.;
Mannan, Rezaul H.;
Wiebe, Leonard I.;
Chapman, J. Donald

Publication type:

Article

Measurement of PDT-Induced Hypoxia in Dunning Prostate Tumors by Iodine-123-Iodoazomycin Arabinoside.

Published in:

Journal of Nuclear Medicine, 1993, v. 34, n. 3, p. 405

By:

Moore, Ronald B.;
Chapman, J. Donald;
Mercer, John R.;
Mannan, Rezaul H.;
Wiebe, Leonard I.;
McEwan, Alexander J.;
McPhee, Malcolm S.

Publication type:

Article

Radioiodinated 1-(5-Iodo-5-deoxy-β-D-arabinofuranosyl)-2-nitroimidazole (Iodoazomycin Arabinoside: IAZA): A Novel Marker of Tissue Hypoxia.

Published in:

Journal of Nuclear Medicine, 1991, v. 32, n. 9, p. 1764

By:

Mannan, Rezaul H.;
Somayaji, Vijayalakashmi V.;
Lee, Jane;
Mercer, John R.;
Chapman, J. Donald;
Wiebe, Leonard I.

Publication type:

Article

High Specific Activity [Samarium-153] EDTA for Imaging of Experimental Tumor Models.

Published in:

Journal of Nuclear Medicine, 1989, v. 30, n. 2, p. 202

By:

Tse, John W.;
Wiebe, Leonard I.;
Noujaim, Antoine A.

Publication type:

Article

Radiolabeling with Organomercury Compounds: Part 2. High Specific Activity Synthesis of Iodine-125 and Iodine-131-6-Iodocholest-5-en-3β-ol and Its Tissue Distribution in Rats.

Published in:

Journal of Nuclear Medicine, 1986, v. 27, n. 7, p. 1165

By:

Flanagan, Richard J.;
Charleson, F. Peter;
Synnes, Eyvind I.;
Wiebe, Leonard I.

Publication type:

Article

Synthesis of 5-(1-azido-2-haloethyl)arabinouridines.

Published in:

Journal of Heterocyclic Chemistry, 1997, v. 34, n. 4, p. 1369, doi. 10.1002/jhet.5570340445

By:

Kumar, Rakesh;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

Synthesis and properties of 5-(1,2-dihaloethyl)-2′-deoxyuridines and related analogues.

Published in:

Journal of Heterocyclic Chemistry, 1991, v. 28, n. 8, p. 1917, doi. 10.1002/jhet.5570280819

By:

Kumar, Rakesh;
Knaus, Edward E.;
Wiebe, Leonard I.

Publication type:

Article

Aziridination of the uracil 5,6-olefinic bond of 3- N-3′,5′-Di- O-tribenzoyl-5-vinyl-2′-deoxyuridine.

Published in:

Journal of Heterocyclic Chemistry, 1991, v. 28, n. 5, p. 1467, doi. 10.1002/jhet.5570280549

By:

Kumar, Rakesh;
Wiebe, Leonard I.;
Knaus, Edward E.;
Nakashima, Thomas T.

Publication type:

Article

Synthesis of brain-targeted 5-iodo-, 5-vinyl- and ( E)-5-(2-iodovinyl)-2′-deoxyuridines coupled to a dihydropyridine ⇌ pyridinium salt redox chemical delivery system.

Published in:

Journal of Heterocyclic Chemistry, 1991, v. 28, n. 3, p. 711, doi. 10.1002/jhet.5570280327

By:

Kumar, Rakesh;
Ji, Gueijun;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

Design and synthesis of the 3′-aminocarbonylamino, aminothiocarbonylamino and N-(Hydroxy)guanidinyl derivatives of thymidine as potential anti-HIV agents.

Published in:

Journal of Heterocyclic Chemistry, 1991, v. 28, n. 3, p. 807, doi. 10.1002/jhet.5570280346

By:

Morin, Kevin W.;
Kumar, Rakesh;
Knaus, Edward E.;
Wiebe, Leonard I.

Publication type:

Article

Synthesis and biological evaluation of 5-(1-alkoxy-2-haloethyl)-2′-deoxyuridines and related uracil analogues.

Published in:

Journal of Heterocyclic Chemistry, 1991, v. 28, n. 2, p. 237, doi. 10.1002/jhet.5570280206

By:

Kumar, Rakesh;
Wiebe, Leonard I.;
Knaus, E. E.;
Tempest, Mark L.

Publication type:

Article

Reaction of 1-(2′,3′-epoxy-β- D-lyxofuranosyl)uracil with hydrogen fluoride. The unexpected formation of 1-(3′-fluoro-3′-deoxy-β- D-ribofuranosyl)uracil.

Published in:

Journal of Heterocyclic Chemistry, 1984, v. 21, n. 3, p. 773, doi. 10.1002/jhet.5570210327

By:

Misra, Hemant K.;
Gati, Wendy P.;
Knaus, Edward E.;
Wiebe, Leonard I.

Publication type:

Article

Synthesis and Biological Evaluation of Butanoate, Retinoate, and Bis(2,2,2-trichloroethyl)phosphate Derivatives of 5-Fluoro-2′-deoxyuridine and 2′,5-Difluoro-2′-deoxyuridine as Potential Dual Action Anticancer Prodrugs.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 8, p. 286, doi. 10.1002/(SICI)1521-4184(19998)332:8<286::AID-ARDP286>3.0.CO;2-9

By:

Xia, Zuping;
Wiebe, Leonard I.;
Miller, Gerald G.;
Knaus, Edward E.

Publication type:

Article

Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy-(or Azido)-5,6-dihydro-2′-deoxyuridine Diastereomers as Potential Prodrugs to 5-Ethyl-2′-deoxyuridine.

Published in:

Archiv der Pharmazie, 1997, v. 330, n. 8, p. 259, doi. 10.1002/ardp.19973300806

By:

Kumar, Rakesh;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

Synthesis and Antifungal Activities of Myristic Acid Analogs.

Published in:

Archiv der Pharmazie, 1996, v. 329, n. 11, p. 475, doi. 10.1002/ardp.19963291102

By:

Parang, Keykavous;
Knaus, Edward E.;
Wiebe, Leonard I.;
Sardari, Soroush;
Daneshtalab, Mohsen;
Csizmadia, Ferenc

Publication type:

Article

Synthesis of [ 18 F]F-γ-T-3, a Redox-Silent γ-Tocotrienol (γ-T-3) Vitamin E Analogue for Image-Based In Vivo Studies of Vitamin E Biodistribution and Dynamics.

Published in:

Molecules, 2020, v. 25, n. 23, p. 5700, doi. 10.3390/molecules25235700

By:

Roselt, Peter;
Cullinane, Carleen;
Noonan, Wayne;
Elsaidi, Hassan;
Eu, Peter;
Wiebe, Leonard I.;
Roivainen, Anne

Publication type:

Article

A Simple Computational Tool for Accurate, Quantitative Prediction of One-Electron Reduction Potentials of Hypoxia-Activated Tirapazamine Analogues.

Published in:

Journal of Pharmacy & Pharmaceutical Sciences, 2020, v. 23, p. 231, doi. 10.18433/jpps30602

By:

Elsaidi, Hassan R. H.;
Wiebe, Leonard I.;
Kumar, Piyush

Publication type:

Article

A Simple Computational Tool for Accurate, Quantitative Prediction of One-Electron Reduction Potentials of Hypoxia-Activated Tirapazamine Analogues.

Published in:

2020

By:

Elsaidi, Hassan R. H.;
Wiebe, Leonard I.;
Kumar, Piyush;
Elsaidi, Hassan Rh

Publication type:

journal article

Positron Emission Tomography (PET) and Pharmacokinetics: Classical Blood Sampling Versus Image-Derived Analysis of [18F]FAZA and [18F]FDG in a Murine Tumor Bearing Model.

Published in:

2018

By:

Jans, Hans-Soenke;
Xiao-Hong Yang;
Brocks, Dion R.;
Kumar, Piyush;
Wuest, Melinda;
Wiebe, Leonard I.;
Yang, Xiao-Hong

Publication type:

journal article

Synthesis and Biological Evaluation of Iodoglucoazomycin (I-GAZ), an Azomycin-Glucose Adduct with Putative Applications in Diagnostic Imaging and Radiotherapy of Hypoxic Tumors.

Published in:

ChemMedChem, 2016, v. 11, n. 15, p. 1638, doi. 10.1002/cmdc.201600213

By:

Kumar, Piyush;
Elsaidi, Hassan R. H.;
Zorniak, Bohdarianna;
Laurens, Evelyn;
Yang, Jennifer;
Bacchu, Veena;
Wang, Monica;
Wiebe, Leonard I.

Publication type:

Article

Effect of acyclovir on the uptake of 131 I-labelled 1-(2′fluoro-2′-deoxy-βD-D-arabinofuranosyl)-5-lodouracil in herpes infected cells.

Published in:

Journal of Medical Virology, 1987, v. 22, n. 2, p. 183, doi. 10.1002/jmv.1890220210

By:

Tovell, Dorothy R.;
Yacyshyn, Harold P.;
Misra, Hemant K.;
Knaus, Edward E.;
Wiebe, Leonard I.;
Samuel, John;
Gill, M. John;
Tyrrell, D. Lorne J.

Publication type:

Article

Comparative Evaluation of Therapeutic Radiopharmaceuticals.

Published in:

Journal of Nuclear Medicine, 2008, v. 49, n. 11, p. 1900, doi. 10.2967/jnumed.108.054288

By:

Wiebe, Leonard I.

Publication type:

Article

Labelling of Small Biomolecules Using Novel Technetium-99m Cores.

Published in:

Journal of Nuclear Medicine, 2008, v. 49, n. 11, p. 1901, doi. 10.2967/jnumed.108.054338

By:

Wiebe, Leonard I.

Publication type:

Article

Hypoxia-Specific Tumor Imaging with 18F-Fluoroazomycin Arabinoside.

Published in:

Journal of Nuclear Medicine, 2005, v. 46, n. 1, p. 106

By:

Piert, Morand;
Machulla, Hans-Jürgen;
Picchio, Maria;
Reischl, Gerald;
Ziegler, Sybille;
Kumar, Piyush;
Wester, Hans-Jürgen;
Beck, Roswitha;
McEwan, Alexander J. B.;
Wiebe, Leonard I.;
Schwaiger, Markus

Publication type:

Article

FDG Metabolism: Quaecumque Sunt Vera….

Published in:

Journal of Nuclear Medicine, 2001, v. 42, n. 11, p. 1679

By:

Wiebe, Leonard I.

Publication type:

Article

Dosimetry Estimations for 123I-IAZA in Healthy Volunteers.

Published in:

Journal of Nuclear Medicine, 2001, v. 42, n. 9, p. 1418

By:

Stypinski, Daria;
McQuarrie, Steve A.;
Wiebe, Leonard I.;
Tam, Yun K.;
Mercer, John R.;
McEwan, Alexander J. B.

Publication type:

Article

Synthesis of 1-(2-deoxy-β- D-ribofuranosyl)-2,4- difluoro-5-(2-halo-1-hydroxyethyl)benzenes and related derivatives: 'thymine replacement' analogs of deoxythymidine for evaluation as antiviral and anticancer agents.

Published in:

Drug Development Research, 2001, v. 52, n. 3, p. 492, doi. 10.1002/ddr.1151

By:

Naimi, Ebrahim;
Wiebe, Leonard I.;
Balzarini, Jan;
De Clercq, Erik;
Knaus, Edward E.

Publication type:

Article

Synthesis and radioiodination of 3-( E)-(2-iodovinyl)-N-acetyl-4-cysteaminylphenol, a putative tyrosinase substrate for imaging neural crest tumours.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1998, v. 41, n. 5, p. 355, doi. 10.1002/(SICI)1099-1344(199805)41:5<355::AID-JLCR88>3.0.CO;2-K

By:

Singh, Shradha;
Jimbow, Kowichi;
Kumar, Piyush;
McEwan, Alexander J.;
Wiebe, Leonard I.

Publication type:

Article

Syntheses of [2-2H]-5-ethynyl-1-(β-D-ribofuranosyl)imidazole-4-carboxamide and 5-ethynyl-1-([5-3H]-β-D-ribofuranosyl)imidazole-4-carboxamide (EICAR).

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1996, v. 38, n. 9, p. 809, doi. 10.1002/(SICI)1099-1344(199609)38:9<809::AID-JLCR899>3.0.CO;2-0

By:

Minakawa, Noriaki;
Matsuda, Akira;
Xia, Zuping;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

An efficient, high specific activity radioiodination of 5-(1-hydroxy/methoxy-2-iodoethyl)-2′-deoxyuridine by isotope exchange labelling in pivalic acid melt.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1990, v. 28, n. 3, p. 247, doi. 10.1002/jlcr.2580280302

By:

Iwashina, Takashi;
Kumar, Rakesh;
Knaus, Edward E.;
Wiebe, Leonard I.

Publication type:

Article

Synthesis of [5-14C]-1,1,12,12-tetraethoxy-4,9-diazadodecane dinitrate.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1989, v. 27, n. 4, p. 449, doi. 10.1002/jlcr.2580270412

By:

Somayaji, Vijayalakshmi V.;
Hall, Tse W.;
Wiebe, Leonard I.;
Knaus, Edward E.;
Demers, James P.

Publication type:

Article

An improved synthesis of [1-14C]-labelled 2-butynedioic acid, succinic acid and succinyl chloride.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1988, v. 25, n. 12, p. 1325, doi. 10.1002/jlcr.2580251206

By:

Somayaji, Vijayalakshmi V.;
Hall, Tse W.;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

Synthesis of [2-14C]-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro(chloro)uracil.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 1987, v. 24, n. 9, p. 1107, doi. 10.1002/jlcr.2580240912

By:

Misra, Hemant K.;
Wiebe, Leonard I.;
Knaus, Edward E.

Publication type:

Article

Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes.

Published in:

Journal of Physiology, 2004, v. 558, n. 3, p. 807, doi. 10.1113/jphysiol.2004.068189

By:

Smith, Kyla M.;
Ng, Amy M. L.;
Yao, Sylvia Y. M.;
Labedz, Kathy A.;
Knaus, Edward E.;
Wiebe, Leonard I.;
Cass, Carol E.;
Baldwin, Stephen A.;
Xing-Zhen Chen;
Karpinski, Edward;
Young, James D.

Publication type:

Article

Dose-dependent pharmacokinetics of 1-(2-Deoxy-β-D- ribofuranosyl)-2,4-difluoro-5-iodobenzene: A potential mimic of 5-iodo-2'-deoxyuridine.

Published in:

Biopharmaceutics & Drug Disposition, 2003, v. 24, n. 9, p. 385, doi. 10.1002/bdd.375

By:

Panteha Khalili;
Ebrahim Naimi;
Wei Yan Sun;
Edward E. Knaus;
Leonard I. Wiebe

Publication type:

Article

Pharmacokinetics and metabolism of the novel synthetic C-nucleoside, 1-(2-deoxy- β-D-ribofuranosyl)-2,4-difluoro- 5-iodobenzene: a potential mimic of 5-iodo-2′-deoxyuridine.

Published in:

Biopharmaceutics & Drug Disposition, 2002, v. 23, n. 3, p. 105, doi. 10.1002/bdd.301

By:

Khalili, Panteha;
Naimi, Ebrahim;
Knaus, Edward E.;
Wiebe, Leonard I.

Publication type:

Article

Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic β -Cyclodextrin Carrier for Nucleosides and Nucleotides.

Published in:

Pharmaceutics, 2024, v. 16, n. 3, p. 323, doi. 10.3390/pharmaceutics16030323

By:

Ryu, Jang-Ha;
Zheng, Weizhong;
Yang, Xiao-Hong;
Elsaidi, Hassan;
Diakur, Jim;
Wiebe, Leonard I.

Publication type:

Article

Radiation Dosimetry of Theragnostic Pairs for Isotopes of Iodine in IAZA.

Published in:

Pharmaceutics, 2022, v. 14, n. 8, p. 1655, doi. 10.3390/pharmaceutics14081655

By:

Jans, Hans-S.;
Stypinski, Daria;
Kumar, Piyush;
Mercer, John R.;
McQuarrie, Stephen A.;
McEwan, Alexander J. B.;
Wiebe, Leonard I.

Publication type:

Article

Improved Formulation of 224 Ra-Labeled Calcium Carbonate Microparticles by Surface Layer Encapsulation and Addition of EDTMP.

Published in:

Pharmaceutics, 2021, v. 13, n. 5, p. 634, doi. 10.3390/pharmaceutics13050634

By:

Li, Ruth Gong;
Lindland, Kim;
Tonstad, Sandra Karen;
Bønsdorff, Tina Bjørnlund;
Juzeniene, Asta;
Westrøm, Sara;
Larsen, Roy Hartvig;
Wiebe, Leonard I.

Publication type:

Article

Pharmacokinetics and Scintigraphic Imaging of the Hypoxia-Imaging Agent [123I]IAZA in Healthy Adults Following Exercise-Based Cardiac Stress.

Published in:

Pharmaceutics, 2018, v. 10, n. 1, p. 25, doi. 10.3390/pharmaceutics10010025

By:

Stypinski, Daria;
McQuarrie, Stephen A.;
McEwan, Alexander J. B.;
Wiebe, Leonard I.

Publication type:

Article

Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia.

Published in:

Pharmaceuticals (14248247), 2019, v. 12, n. 1, p. 3, doi. 10.3390/ph12010003

By:

Elsaidi, Hassan;
Ahmadi, Fatemeh;
Wiebe, Leonard I.;
Kumar, Piyush

Publication type:

Article

18F-FESB: synthesis and automated radiofluorination of a novel 18F-labeled pet tracer for β-amyloid plaques.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2005, v. 48, n. 13, p. 983, doi. 10.1002/jlcr.1011

By:

Kumar, Piyush;
Zheng, Weizhong;
McQuarrie, Stephen A.;
Jhamandas, Jack H.;
Wiebe, Leonard I.

Publication type:

Article

Initial results of hypoxia imaging using 1-α-D-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA).

Published in:

European Journal of Nuclear Medicine & Molecular Imaging, 2009, v. 36, n. 10, p. 1565, doi. 10.1007/s00259-009-1154-5

By:

Postema, Ernst J.;
McEwan, Alexander J. B.;
Riauka, Terence A.;
Kumar, Piyush;
Richmond, Dacia A.;
Abrams, Douglas N.;
Wiebe, Leonard I.

Publication type:

Article

654. Targeting Adenoviral Vectors for Use in Breast Cancer Gene Therapy.

Published in:

Molecular Therapy, 2006, v. 13, p. S252, doi. 10.1016/j.ymthe.2006.08.730

By:

DeSilva, Alan D.;
Wiebe, Leonard I.;
Chang-Xin Shi;
Elgadi, Mabrouk M.;
Bossi, Gianluca;
Hitt, Mary M.

Publication type:

Article